Welcome to LookChem.com Sign In|Join Free
  • or

Encyclopedia

(2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester

Base Information Edit
  • Chemical Name:(2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester
  • CAS No.:328086-61-9
  • Molecular Formula:C11H18N2O3
  • Molecular Weight:226.276
  • Hs Code.:
  • Mol file:328086-61-9.mol
(2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester

Synonyms:ethyl (S,E)-4-((tert-butoxycarbonyl)amino)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate

Suppliers and Price of (2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • (2E,4S)-4-Amino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoicAcidEthylEster
  • 100mg
  • $ 1230.00
  • Medical Isotopes, Inc.
  • (2E,4S)-4-Amino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoicAcidEthylEster
  • 100 mg
  • $ 2120.00
  • Medical Isotopes, Inc.
  • (2E,4S)-4-Amino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoicAcidEthylEster
  • 10 mg
  • $ 640.00
Total 1 raw suppliers
Chemical Property of (2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester Edit
Chemical Property:
  • Boiling Point:435.0±25.0 °C(Predicted) 
  • PKA:16.38±0.40(Predicted) 
  • Density:1.117±0.06 g/cm3(Predicted) 
  • Solubility.:Dichloromethane, Ethyl Acetate, Methanol 
Purity/Quality:

(2E,4S)-4-Amino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoicAcidEthylEster *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:
Useful:
  • Uses (2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester is used in the preparation of Rhinovirus protease inhibitors.
Technology Process of (2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester

There total 13 articles about (2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
Multi-step reaction with 9 steps
1.1: Me3SiCl / 0 - 23 °C
2.1: 5.55 g / Et3N / methanol / 1 h
3.1: LHMDS / hexane; tetrahydrofuran / 1 h / -78 °C
3.2: 79 percent / hexane; tetrahydrofuran / 2 h / -78 °C
4.1: H2 / PtO2 / CHCl3; methanol / 36 h / 2585.74 Torr
5.1: 4.2 g / Na2CO3 / CHCl3; methanol / 6 h / pH 7 / Heating
6.1: 91 percent / LiBH4 / CH2Cl2; tetrahydrofuran / 1.5 h / 23 °C
7.1: pyridine*SO3; DMSO; Et3N / CH2Cl2 / 2 h / 0 - 23 °C
8.1: 191 mg / CH2Cl2 / 2 h / 23 °C
9.1: TFA / CH2Cl2 / 1 h / 0 °C
With lithium borohydride; chloro-trimethyl-silane; hydrogen; sulfur trioxide pyridine complex; sodium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; platinum(IV) oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; 8.1: Wittig reaction;
DOI:10.1021/jm050548m
Guidance literature:
Multi-step reaction with 7 steps
1.1: LHMDS / hexane; tetrahydrofuran / 1 h / -78 °C
1.2: 79 percent / hexane; tetrahydrofuran / 2 h / -78 °C
2.1: H2 / PtO2 / CHCl3; methanol / 36 h / 2585.74 Torr
3.1: 4.2 g / Na2CO3 / CHCl3; methanol / 6 h / pH 7 / Heating
4.1: 91 percent / LiBH4 / CH2Cl2; tetrahydrofuran / 1.5 h / 23 °C
5.1: pyridine*SO3; DMSO; Et3N / CH2Cl2 / 2 h / 0 - 23 °C
6.1: 191 mg / CH2Cl2 / 2 h / 23 °C
7.1: TFA / CH2Cl2 / 1 h / 0 °C
With lithium borohydride; hydrogen; sulfur trioxide pyridine complex; sodium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; platinum(IV) oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; 6.1: Wittig reaction;
DOI:10.1021/jm050548m
Post RFQ for Price