(2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester

Base Information

Chemical Name:(2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester
CAS No.:328086-61-9
Molecular Formula:C₁₁H₁₈N₂O₃
Molecular Weight:226.276
Hs Code.:
Mol file:328086-61-9.mol

Synonyms:ethyl (S,E)-4-((tert-butoxycarbonyl)amino)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate

Suppliers and Price of (2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2E,4S)-4-Amino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoicAcidEthylEster
100mg
$ 1230.00

Medical Isotopes, Inc.
(2E,4S)-4-Amino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoicAcidEthylEster
100 mg
$ 2120.00

Medical Isotopes, Inc.
(2E,4S)-4-Amino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoicAcidEthylEster
10 mg
$ 640.00

Total 1 raw suppliers

Chemical Property of (2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester

Chemical Property:

Boiling Point:435.0±25.0 °C(Predicted)
PKA:16.38±0.40(Predicted)
Density:1.117±0.06 g/cm3(Predicted)
Solubility.:Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:: (2E,4S)-4-Amino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoicAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester is used in the preparation of Rhinovirus protease inhibitors.

Technology Process of (2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester

There total 13 articles about (2E,4S)-4-AMino-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 328086-54-0
(2E,4S)-4-(tert-butoxycarbonylamino)-5-[(3'S)-2'-oxo-3'-pyrrolidinyl]-2-pentenoic acid ethyl ester

: 328086-61-9
ethyl (S,E)-4-((tert-butoxycarbonyl)amino)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate

Guidance literature:: With hydrogenchloride; In ethanol; at 20 ℃; for 1h;
DOI:10.1021/jm010435c

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 328086-61-9
ethyl (S,E)-4-((tert-butoxycarbonyl)amino)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: Me₃SiCl / 0 - 23 °C

2.1: 5.55 g / Et₃N / methanol / 1 h

3.1: LHMDS / hexane; tetrahydrofuran / 1 h / -78 °C

3.2: 79 percent / hexane; tetrahydrofuran / 2 h / -78 °C

4.1: H₂ / PtO₂ / CHCl₃; methanol / 36 h / 2585.74 Torr

5.1: 4.2 g / Na₂CO₃ / CHCl₃; methanol / 6 h / pH 7 / Heating

6.1: 91 percent / LiBH₄ / CH₂Cl₂; tetrahydrofuran / 1.5 h / 23 °C

7.1: pyridine*SO₃; DMSO; Et₃N / CH₂Cl₂ / 2 h / 0 - 23 °C

8.1: 191 mg / CH₂Cl₂ / 2 h / 23 °C

9.1: TFA / CH₂Cl₂ / 1 h / 0 °C

With lithium borohydride; chloro-trimethyl-silane; hydrogen; sulfur trioxide pyridine complex; sodium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; platinum(IV) oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; 8.1: Wittig reaction;
DOI:10.1021/jm050548m

Reference yield:

: 59279-60-6,130622-05-8,861658-15-3
dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate

: 328086-61-9
ethyl (S,E)-4-((tert-butoxycarbonyl)amino)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: LHMDS / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 79 percent / hexane; tetrahydrofuran / 2 h / -78 °C

2.1: H₂ / PtO₂ / CHCl₃; methanol / 36 h / 2585.74 Torr

3.1: 4.2 g / Na₂CO₃ / CHCl₃; methanol / 6 h / pH 7 / Heating

4.1: 91 percent / LiBH₄ / CH₂Cl₂; tetrahydrofuran / 1.5 h / 23 °C

5.1: pyridine*SO₃; DMSO; Et₃N / CH₂Cl₂ / 2 h / 0 - 23 °C

6.1: 191 mg / CH₂Cl₂ / 2 h / 23 °C

7.1: TFA / CH₂Cl₂ / 1 h / 0 °C

With lithium borohydride; hydrogen; sulfur trioxide pyridine complex; sodium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; platinum(IV) oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; 6.1: Wittig reaction;
DOI:10.1021/jm050548m