5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

Base Information

Chemical Name:5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine
CAS No.:1149335-15-8
Molecular Formula:C₂₂H₂₂N₂O₃
Molecular Weight:362.428
Hs Code.:

Synonyms:5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

Chemical Property:

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Technology Process of 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

There total 3 articles about 5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 123043-88-9,33458-26-3
5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione

: 70-11-1
α-bromoacetophenone

: 1149335-15-8
5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

Guidance literature:: 5-ethoxycarbonyl-4-phenyl-6-methyl-3,4-dihydropyrimidine-2(1H)-thione; α-bromoacetophenone; With potassium carbonate; In acetone; at 20 ℃; for 0.5h;

In acetone; at 80 ℃; for 10h;
DOI:10.1016/j.tetlet.2009.02.027

Reference yield:

: 1149335-28-3
C₂₂H₂₂N₂O₃S

: 1149335-15-8
5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

Guidance literature:: With triisopropyl phosphite; In 1,4-dioxane; at 220 ℃; for 0.0194444h; under 75007.5 Torr;
DOI:10.3762/bjoc.7.135

Reference yield:

: 33458-26-3
ethyl 2-mercapto-6-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylate

: 1149335-15-8
5-ethoxycarbonyl-6-methyl-4-phenyl-2-(2-hydroxy-2-phenylvinyl)-1,4-dihydropyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1,4-dioxane / 1 h / Sonication; Heating

2: triisopropyl phosphite / 1,4-dioxane / 0.02 h / 220 °C / 75007.5 Torr

With triisopropyl phosphite; triethylamine; In 1,4-dioxane; 2: Eschenmoser coupling;
DOI:10.3762/bjoc.7.135