cinchonidine 11,11-dimethyl-O-⁽⁹⁾-benzyl ether

Base Information

• Chemical Name: cinchonidine 11,11-dimethyl-O-⁽⁹⁾-benzyl ether
• CAS No.: 1246968-56-8
• Molecular Formula: C₂₈H₃₂N₂O
• Molecular Weight: 412.575
• Mol file: 1246968-56-8.mol

Synonyms:cinchonidine 11,11-dimethyl-O-⁽⁹⁾-benzyl ether

Chemical Property of cinchonidine 11,11-dimethyl-O-⁽⁹⁾-benzyl ether

Chemical Property:

Purity/Quality:

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Technology Process of cinchonidine 11,11-dimethyl-O-⁽⁹⁾-benzyl ether

There total 1 articles about cinchonidine 11,11-dimethyl-O-⁽⁹⁾-benzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

cinchonidine 11,11-dimethyl-9-acetate (1246968-55-7) + benzyl bromide (100-39-0) → cinchonidine 11,11-dimethyl-O-(9)-benzyl ether (1246968-56-8)

Guidance literature:

cinchonidine 11,11-dimethyl-9-acetate; With sodium hydroxide; In methanol; water; at 20 ℃; Inert atmosphere;

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ja1057828

Reference yield: 47.0%

cinchonidine 11,11-dimethyl-O-(9)-benzyl ether (1246968-56-8) + 1,3-bis-(bromomethyl)benzene (626-15-3) → α,α'-bis[O-(9)-benzyl-11,11-dimethylcinchonidinium]-m-xylene dibromide

Guidance literature:

In tetrahydrofuran; at 67 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ja1057828

upstream raw materials:

cinchonidine 11,11-dimethyl-9-acetate

benzyl bromide