4-[5-amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-ylmethyl]-phenol

Base Information

Chemical Name:4-[5-amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-ylmethyl]-phenol
CAS No.:1187227-37-7
Molecular Formula:C₁₆H₁₂F₄N₄O
Molecular Weight:352.291
Hs Code.:

Synonyms:4-[5-amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-ylmethyl]-phenol

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Chemical Property of 4-[5-amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-ylmethyl]-phenol

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Technology Process of 4-[5-amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-ylmethyl]-phenol

There total 2 articles about 4-[5-amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-ylmethyl]-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1187227-36-6
5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine

: 1187227-37-7
4-[5-amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-ylmethyl]-phenol

Guidance literature:: 5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine; With boron tribromide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With methanol; water; In dichloromethane; Cooling with ice;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1187227-37-7
4-[5-amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-ylmethyl]-phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide / ethanol; water / 24 h / Reflux

2.1: sodium methylate / methanol / 20 °C / Cooling with ice

3.1: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere

3.2: Cooling with ice

With sodium azide; sodium methylate; boron tribromide; In methanol; ethanol; dichloromethane; water;