5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine

Base Information

Chemical Name:5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine
CAS No.:1187227-36-6
Molecular Formula:C₁₇H₁₄F₄N₄O
Molecular Weight:366.318
Hs Code.:

Synonyms:5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine

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Technology Process of 5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine

There total 2 articles about 5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 239087-11-7
[2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile

: 70978-37-9
1-(azidomethyl)-4-methoxybenzene

: 1187227-36-6
5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; Cooling with ice;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1187227-36-6
5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / ethanol; water / 24 h / Reflux

2: sodium methylate / methanol / 20 °C / Cooling with ice

With sodium azide; sodium methylate; In methanol; ethanol; water;

Reference yield: 57.0%

: 1187227-36-6
5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine

: 1187227-37-7
4-[5-amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-ylmethyl]-phenol

Guidance literature:: 5-(2-fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-benzyl)-3H-[1,2,3]triazol-4-ylamine; With boron tribromide; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With methanol; water; In dichloromethane; Cooling with ice;