4,5-dimethyl-3,6-diphenyl-2-[1-(1-hydroxymethyl-2,2-dimethylpropyl)amino]carbonyl-1-phospha-2,5-norbornadiene sulfide

Base Information

Chemical Name:4,5-dimethyl-3,6-diphenyl-2-[1-(1-hydroxymethyl-2,2-dimethylpropyl)amino]carbonyl-1-phospha-2,5-norbornadiene sulfide
CAS No.:299924-48-4
Molecular Formula:C₂₇H₃₂NO₂PS
Molecular Weight:465.596
Hs Code.:

Synonyms:4,5-dimethyl-3,6-diphenyl-2-[1-(1-hydroxymethyl-2,2-dimethylpropyl)amino]carbonyl-1-phospha-2,5-norbornadiene sulfide

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Chemical Property of 4,5-dimethyl-3,6-diphenyl-2-[1-(1-hydroxymethyl-2,2-dimethylpropyl)amino]carbonyl-1-phospha-2,5-norbornadiene sulfide

Chemical Property:

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Technology Process of 4,5-dimethyl-3,6-diphenyl-2-[1-(1-hydroxymethyl-2,2-dimethylpropyl)amino]carbonyl-1-phospha-2,5-norbornadiene sulfide

There total 7 articles about 4,5-dimethyl-3,6-diphenyl-2-[1-(1-hydroxymethyl-2,2-dimethylpropyl)amino]carbonyl-1-phospha-2,5-norbornadiene sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112245-13-3
(S)-tert-leucinol

: 299924-42-8
3,6-diphenyl-4,5-dimethyl-2-hydroxycarbonyl-1-phospha-2,5-norbornadiene sulfide

: 299924-48-4
4,5-dimethyl-3,6-diphenyl-2-[1-(1-hydroxymethyl-2,2-dimethylpropyl)amino]carbonyl-1-phospha-2,5-norbornadiene sulfide

: 299924-47-3
4,5-dimethyl-3,6-diphenyl-2-[1-(1-hydroxymethyl-2,2-dimethylpropyl)amino]carbonyl-1-phospha-2,5-norbornadiene sulfide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/ol006323h

Reference yield:

: 299924-63-3
4,5-dimethyl-2-methoxycarbonyl-3,6-diphenyl-1-phospha-2,5-norbornadiene

: 299924-48-4
4,5-dimethyl-3,6-diphenyl-2-[1-(1-hydroxymethyl-2,2-dimethylpropyl)amino]carbonyl-1-phospha-2,5-norbornadiene sulfide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / S₈ / toluene / 12 h / 90 - 95 °C

2: LiI / pyridine / 20 h / 150 °C

3: 0.27 g / EDCl; HOBT / dimethylformamide / 0 - 20 °C

With sulfur; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide; In pyridine; N,N-dimethyl-formamide; toluene; 1: Oxidation / 2: Hydrolysis / 3: Condensation;
DOI:10.1021/ol006323h

Reference yield:

: 4,5-dimethyl-2-pethoxycarbonyl-3,6-diphenyl-1-phospha-2,5-norbornadiene

: 299924-48-4
4,5-dimethyl-3,6-diphenyl-2-[1-(1-hydroxymethyl-2,2-dimethylpropyl)amino]carbonyl-1-phospha-2,5-norbornadiene sulfide

Guidance literature:: Multi-step reaction with 3 steps

1: S₈ / toluene / 12 h / 90 - 95 °C

2: LiOH*H₂O / tetrahydrofuran; ethanol; H₂O / 15 h / 0 - 20 °C

3: 0.27 g / EDCl; HOBT / dimethylformamide / 0 - 20 °C

With sulfur; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; 1: Oxidation / 2: Hydrolysis / 3: Condensation;
DOI:10.1021/ol006323h