methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoroethyl)benzoate

Base Information

Chemical Name:methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoroethyl)benzoate
CAS No.:299173-18-5
Molecular Formula:C₂₆H₂₄F₂O₄
Molecular Weight:438.471
Hs Code.:

Synonyms:methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoroethyl)benzoate

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Chemical Property of methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoroethyl)benzoate

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Technology Process of methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoroethyl)benzoate

There total 6 articles about methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoroethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

: 299173-17-4
methyl 4-(1,1-difluoroethyl)-2-iodobenzoate

: 204981-46-4
(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)boronic acid

: 299173-18-5
methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoroethyl)benzoate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 100 ℃; for 4h;

Reference yield:

: 165534-79-2
dimethyl 2-iodoterephthalate

: 299173-18-5
methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoroethyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 59.9 percent / LiOH*H₂O / methanol; H₂O / 3.33 h / 20 °C

2: 100 percent / thionyl chloride / CH₂Cl₂; dimethylformamide / 2 h / Heating

3: 40.8 percent / LiCl; CuCN / tetrahydrofuran / 18 h / 0 - 20 °C

4: 42.5 percent / DAST / 24 h / 20 °C

5: 93.8 percent / Na₂CO₃ / Pd(Ph₃P)4 / H₂O; toluene / 4 h / 100 °C

With lithium hydroxide; thionyl chloride; sodium carbonate; 4,4'-diaminostilbene-2,2'-disulfonic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Hydrolysis / 2: Chlorination / 3: Grignard reaction / 4: Fluorination / 5: Arylation;

Reference yield:

: 299173-16-3
methyl 4-acetyl-2-iodobenzoate

: 299173-18-5
methyl 2-(3S,4R)-(3-benzyl-4-hydroxychroman-7-yl)-4-(1,1-difluoroethyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 42.5 percent / DAST / 24 h / 20 °C

2: 93.8 percent / Na₂CO₃ / Pd(Ph₃P)4 / H₂O; toluene / 4 h / 100 °C

With sodium carbonate; 4,4'-diaminostilbene-2,2'-disulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; 1: Fluorination / 2: Arylation;