(S)-N-(8-benzyl-3-methyl-7-oxo-8-azaspiro[5.5]undec-2-en-1-ylidene)-L-valine diethylamide

Base Information

Chemical Name:(S)-N-(8-benzyl-3-methyl-7-oxo-8-azaspiro[5.5]undec-2-en-1-ylidene)-L-valine diethylamide
CAS No.:565230-24-2
Molecular Formula:C₂₇H₃₉N₃O₂
Molecular Weight:437.626
Hs Code.:

Synonyms:(S)-N-(8-benzyl-3-methyl-7-oxo-8-azaspiro[5.5]undec-2-en-1-ylidene)-L-valine diethylamide

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Chemical Property of (S)-N-(8-benzyl-3-methyl-7-oxo-8-azaspiro[5.5]undec-2-en-1-ylidene)-L-valine diethylamide

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Technology Process of (S)-N-(8-benzyl-3-methyl-7-oxo-8-azaspiro[5.5]undec-2-en-1-ylidene)-L-valine diethylamide

There total 3 articles about (S)-N-(8-benzyl-3-methyl-7-oxo-8-azaspiro[5.5]undec-2-en-1-ylidene)-L-valine diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 78-94-4,25038-87-3
methyl vinyl ketone

: 565230-21-9
N-[1-(3-benzyl-2-oxo-3-azacyclohexylidene)ethyl]-L-valine diethylamide

: 565230-24-2
(S)-N-(8-benzyl-3-methyl-7-oxo-8-azaspiro[5.5]undec-2-en-1-ylidene)-L-valine diethylamide

Guidance literature:: With copper diacetate; In acetone; at 23 ℃; for 16h;
DOI:10.1002/ejoc.200300191

Reference yield:

: 56414-87-0
(2S)-2-amino-N,N-diethyl-3-methylbutanamide

: 565230-24-2
(S)-N-(8-benzyl-3-methyl-7-oxo-8-azaspiro[5.5]undec-2-en-1-ylidene)-L-valine diethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / molecular sieves 4 Angstroem; concd. H₂SO₄ / toluene / 16 h / 60 °C

2: 37 percent / Cu(OAc)2*H₂O / acetone / 16 h / 23 °C

With copper diacetate; 4 A molecular sieve; sulfuric acid; In acetone; toluene;
DOI:10.1002/ejoc.200300191

Reference yield:

: 530103-60-7
α-acetyl-N-benzyl-γ-valerolactam

: 565230-24-2
(S)-N-(8-benzyl-3-methyl-7-oxo-8-azaspiro[5.5]undec-2-en-1-ylidene)-L-valine diethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / molecular sieves 4 Angstroem; concd. H₂SO₄ / toluene / 16 h / 60 °C

2: 37 percent / Cu(OAc)2*H₂O / acetone / 16 h / 23 °C

With copper diacetate; 4 A molecular sieve; sulfuric acid; In acetone; toluene;
DOI:10.1002/ejoc.200300191