Amitraz

Base Information

• Chemical Name: Amitraz
• CAS No.: 33089-61-1
• Molecular Formula: C19H23N3
• Molecular Weight: 293.412
• Hs Code.: 29252900
• European Community (EC) Number: 251-375-4
• ICSC Number: 0098
• NSC Number: 758952,324552
• UN Number: 2588
• UNII: 33IAH5017S
• DSSTox Substance ID: DTXSID5023871
• Nikkaji Number: J1.887B
• Wikipedia: Amitraz
• Wikidata: Q417878
• NCI Thesaurus Code: C74339
• ChEMBL ID: CHEMBL1365675
• Mol file: 33089-61-1.mol

Synonyms:amitraz;Mitaban;N-methyl-bis(2,4-xylyiminomethyl) amine;Taktic;U 36059

Chemical Property of Amitraz

Chemical Property:

• Appearance/Colour: white
• Vapor Pressure: 2.57E-08mmHg at 25°C
• Melting Point: 86-87 °C
• Refractive Index: 1.546
• Boiling Point: 450.7 °C at 760 mmHg
• PKA: 4.2 (weak base)
• Flash Point: 226.4 °C
• PSA: 27.96000
• Density: 0.98 g/cm³
• LogP: 4.87180
• Storage Temp.: 0-6°C
• Water Solubility.: 0.08 mg l-1
• XLogP3: 5.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 293.189197746
• Heavy Atom Count: 22
• Complexity: 354

Purity/Quality:

95% ^*data from raw suppliers

Amitraz ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn;N,N,Xn
• Statements: 22-43-48/22-50/53
• Safety Statements: 22-24-36/37-60-61

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Pesticides -> Other Insecticides
• Canonical SMILES: CC1=CC(=C(C=C1)N=CN(C)C=NC2=C(C=C(C=C2)C)C)C
• Inhalation Risk: No indication can be given about the rate at which a harmful concentration of this substance in the air is reached.
• Effects of Short Term Exposure: The substance may cause effects on the central nervous system and cardiovascular system.
• Uses: Amitraz is used for the control of all stages of mites and insects such as aphids and whitefly, and the eggs and first instar larvae of Lepidoptera on fruit, cotton and vegetables. It is also used in honey bee hives and for the control of ticks, mites and lice on domestic and farm animals. coccidiostat, antiplatelet Amitraz is an antiparasitic used to control red spider mites, leaf miners and scale insects. This compound is active by inhibiting the targets monoaminooxidase enzyme. Acaricide; insecticide.
• Therapeutic Function: Acaricide, Scabicide, Tickicide, Appetite stimulant

Technology Process of Amitraz

There total 2 articles about Amitraz which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.34%

N-Methylformamide (123-39-7) + 2,4-Xylidine (95-68-1) → Amitraz (33089-61-1)

Guidance literature:

With 2,4-xylidine hydrochloride; orthoformic acid triethyl ester; zinc(II) chloride; at 95 - 180 ℃;

Reference yield:

→ Amitraz (33089-61-1)

Guidance literature:

ArN=CHOEt, ArN=CH-NHR;

upstream raw materials:

N-Methylformamide

2,4-Xylidine

Refernces

• 1、 -. "Macrocyclic plant acaricides". . . Retrieved 2008/06/13.