4-[(S)-1-(4-chloro-3-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

Base Information

Chemical Name:4-[(S)-1-(4-chloro-3-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide
CAS No.:1612242-37-1
Molecular Formula:C₁₈H₁₆ClF₃N₆O
Molecular Weight:424.813
Hs Code.:

Synonyms:4-[(S)-1-(4-chloro-3-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

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Chemical Property of 4-[(S)-1-(4-chloro-3-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

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Technology Process of 4-[(S)-1-(4-chloro-3-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

There total 11 articles about 4-[(S)-1-(4-chloro-3-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1612242-76-8
C₂₄H₁₉ClF₃N₇O₅S

: 1612242-37-1
4-[(S)-1-(4-chloro-3-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

Guidance literature:: With mercaptoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃;

Reference yield:

: 1612242-74-6
C₂₅H₂₀ClF₃N₆O₆S

: 1612242-37-1
4-[(S)-1-(4-chloro-3-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / methanol / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene; mercaptoacetic acid / acetonitrile / 20 °C

With ammonia; mercaptoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; acetonitrile;

Reference yield:

: 1378825-44-5
4-methyl-3-nitropicolinonitrile

: 1612242-37-1
4-[(S)-1-(4-chloro-3-trifluoromethyl-phenyl)-2-methylamino-ethylamino]-pyrido[3,2-d]pyrimidine-8-carboxylic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / water / 3 h / 70 °C

2.1: hydrogenchloride; ammonium chloride; iron / water; isopropyl alcohol / Reflux

3.1: 24 h / Reflux

4.1: sulfuric acid; potassium dichromate; Pyrimidin-2(1H)-one / water / 20 - 30 °C

5.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 70 °C

5.2: 70 °C

6.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere

6.2: 40 °C

7.1: ammonia / methanol / 20 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; mercaptoacetic acid / acetonitrile / 20 °C

With Pyrimidin-2(1H)-one; hydrogenchloride; potassium dichromate; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonia; iron; ammonium chloride; mercaptoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; methanol; water; dimethyl sulfoxide; isopropyl alcohol; acetonitrile;