(5S)-2-methyl-5-[(1S)-1-tert-butoxycarbonylamino-2-tert-butyldiphenylsilanyloxyethyl]-3-oxo-2,3,4,5-tetrahydropyridazine

Base Information

Chemical Name:(5S)-2-methyl-5-[(1S)-1-tert-butoxycarbonylamino-2-tert-butyldiphenylsilanyloxyethyl]-3-oxo-2,3,4,5-tetrahydropyridazine
CAS No.:888949-16-4
Molecular Formula:C₂₈H₃₉N₃O₄Si
Molecular Weight:509.721
Hs Code.:

Synonyms:(5S)-2-methyl-5-[(1S)-1-tert-butoxycarbonylamino-2-tert-butyldiphenylsilanyloxyethyl]-3-oxo-2,3,4,5-tetrahydropyridazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S)-2-methyl-5-[(1S)-1-tert-butoxycarbonylamino-2-tert-butyldiphenylsilanyloxyethyl]-3-oxo-2,3,4,5-tetrahydropyridazine

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Technology Process of (5S)-2-methyl-5-[(1S)-1-tert-butoxycarbonylamino-2-tert-butyldiphenylsilanyloxyethyl]-3-oxo-2,3,4,5-tetrahydropyridazine

There total 2 articles about (5S)-2-methyl-5-[(1S)-1-tert-butoxycarbonylamino-2-tert-butyldiphenylsilanyloxyethyl]-3-oxo-2,3,4,5-tetrahydropyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 60-34-4
methylhydrazine

: 691407-26-8
(4S,5S)-N-tert-butoxycarbonyl-5-tert-butyldiphenylsilyloxymethyl-2-oxopyrrolidine-4-carbaldehyde

: 888949-16-4
(5S)-2-methyl-5-[(1S)-1-tert-butoxycarbonylamino-2-tert-butyldiphenylsilanyloxyethyl]-3-oxo-2,3,4,5-tetrahydropyridazine

Guidance literature:: In methanol; at 20 ℃; for 18h;
DOI:10.1039/b600195e

Reference yield:

: 144564-14-7
(4R,5S)-1-tert-butyloxycarbonyl-5-((tert-butyldiphenylsilyl)oxymethyl)-4-vinylpyrrolidin-2-one

: 888949-16-4
(5S)-2-methyl-5-[(1S)-1-tert-butoxycarbonylamino-2-tert-butyldiphenylsilanyloxyethyl]-3-oxo-2,3,4,5-tetrahydropyridazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / CH₂Cl₂ / 0.25 h / -78 °C

1.2: 96 percent / PPh₃ / CH₂Cl₂ / 1 h / 20 °C

2.1: 65 percent / methanol / 18 h / 20 °C

With ozone; In methanol; dichloromethane;
DOI:10.1039/b600195e