Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester

Base Information

• Chemical Name: Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester
• CAS No.: 107036-23-7
• Molecular Formula: C₂₁H₂₁ClO₅
• Molecular Weight: 388.848
• Mol file: 107036-23-7.mol

Synonyms:Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester

Chemical Property of Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester

There total 3 articles about Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R*,3S*)-2,3-bis(4-acetoxyphenyl)pentanoic acid (83303-74-6,102448-66-8) → Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester (107036-23-7)

Guidance literature:

With pyridine; thionyl chloride; In chloroform; at 50 ℃; for 18h;

DOI:10.1021/jm00353a006

Reference yield:

(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanoic acid (83303-72-4) → Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester (107036-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / conc. H₂SO₄ / 0.33 h / Ambient temperature

2: thionyl chloride, pyridine / CHCl₃ / 18 h / 50 °C

With pyridine; thionyl chloride; sulfuric acid; In chloroform;

DOI:10.1021/jm00353a006

Reference yield:

(2R*,3S*)-2,3-bis(4-methoxyphenyl)pentanoic acid (1756-65-6,29551-34-6,53530-38-4,53625-21-1,83349-89-7) → Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester (107036-23-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / BBr₃ / CH₂Cl₂ / 1.) -40 deg C, 30 min, 2.) 4 deg C, 4 h

2: 98 percent / conc. H₂SO₄ / 0.33 h / Ambient temperature

3: thionyl chloride, pyridine / CHCl₃ / 18 h / 50 °C

With pyridine; thionyl chloride; sulfuric acid; boron tribromide; In dichloromethane; chloroform;

DOI:10.1021/jm00353a006

upstream raw materials:

(2R*,3S*)-2,3-bis(4-acetoxyphenyl)pentanoic acid

(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanoic acid

(2R*,3S*)-2,3-bis(4-methoxyphenyl)pentanoic acid

Downstream raw materials:

3-iodoethyl (2R*,3S*)-2,3-bis(4-acetoxyphenyl)pentanoate

3-bromopropyl (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanoate

3-iodoethyl (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanoate

(2R*,3S*)-1-<2,3-bis(4-hydroxyphenyl)-1-pentanoyl>aziridine