2,3-bis(4-methoxyphenyl)pentanoic acid

Base Information

• Chemical Name: 2,3-bis(4-methoxyphenyl)pentanoic acid
• CAS No.: 1756-65-6
• Molecular Formula: C₁₉H₂₂O₄
• Molecular Weight: 314.381
• Mol file: 1756-65-6.mol

Synonyms:Valericacid, 2,3-bis(p-methoxyphenyl)- (6CI,7CI); Valeric acid,2,3-bis(p-methoxyphenyl)-, (+)- (8CI); NSC 10947

Chemical Property of 2,3-bis(4-methoxyphenyl)pentanoic acid

Chemical Property:

• Vapor Pressure: 1.54E-08mmHg at 25°C
• Boiling Point: 440.5°C at 760 mmHg
• Flash Point: 152.6°C
• Density: 1.136g/cm³

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-bis(4-methoxyphenyl)pentanoic acid

There total 8 articles about 2,3-bis(4-methoxyphenyl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2,3-Bis(4-methoxyphenyl)valeronitril (79568-15-3) → (2R*,3S*)-2,3-bis(4-methoxyphenyl)pentanoic acid (1756-65-6,29551-34-6,53530-38-4,53625-21-1,83349-89-7)

Guidance literature:

With sodium hydroxide; In ethylene glycol; for 48h; Heating;

DOI:10.1002/ardp.19833160316

Reference yield:

2,3-bis-(4-methoxy-phenyl)-valeronitrile (63785-35-3) → 2,3-bis-(4-methoxy-phenyl)-valeric acid (1756-65-6)

Guidance literature:

With sodium hydroxide; ethylene glycol;

DOI:10.1021/ja01190a059

Reference yield:

p-methoxy-α-p-methoxyphenylcinnamonitrile (6443-74-9) → (2R*,3S*)-2,3-bis(4-methoxyphenyl)pentanoic acid (1756-65-6,29551-34-6,53530-38-4,53625-21-1,83349-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg / 1.) ether, 2.) THF, reflux, 1 h; room temp., 20 h

2: 42 percent / aq. NaOH / ethane-1,2-diol / 48 h / Heating

With sodium hydroxide; magnesium; In ethylene glycol;

DOI:10.1002/ardp.19833160316

upstream raw materials:

2,3-bis-(4-methoxy-phenyl)-valeronitrile

2,3-bis-(4-methoxy-phenyl)-valeric acid methyl ester

(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanoic acid

dimethyl sulfate

Downstream raw materials:

(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanoic acid

Acetic acid 4-[(1S,2R)-2-(4-acetoxy-phenyl)-1-chlorocarbonyl-butyl]-phenyl ester

(3R*,4S*)-3,4-bis(4-hydroxyphenyl)-5-nonanone

(3R*,4S*)-3,4-bis(4-hydroxyphenyl)-2-hexanone