1,1′-(2′-(1H-pyrazol-1-yl)[1,1′:3′,1′′-terphenyl]-4,4′′-diyl)bis(ethan-1-one)

Base Information

• Chemical Name: 1,1′-(2′-(1H-pyrazol-1-yl)[1,1′:3′,1′′-terphenyl]-4,4′′-diyl)bis(ethan-1-one)
• CAS No.: 1041085-99-7
• Molecular Formula: C₂₅H₂₀N₂O₂
• Molecular Weight: 380.446
• Mol file: 1041085-99-7.mol

Synonyms:1,1′-(2′-(1H-pyrazol-1-yl)[1,1′:3′,1′′-terphenyl]-4,4′′-diyl)bis(ethan-1-one)

Chemical Property of 1,1′-(2′-(1H-pyrazol-1-yl)[1,1′:3′,1′′-terphenyl]-4,4′′-diyl)bis(ethan-1-one)

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1,1′-(2′-(1H-pyrazol-1-yl)[1,1′:3′,1′′-terphenyl]-4,4′′-diyl)bis(ethan-1-one)

There total 5 articles about 1,1′-(2′-(1H-pyrazol-1-yl)[1,1′:3′,1′′-terphenyl]-4,4′′-diyl)bis(ethan-1-one) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-phenylpyrazole (1126-00-7) + para-bromoacetophenone (99-90-1) → 1-(2′-(1H-pyrazol-1-yl)[1,1′-biphenyl]-4-yl)ethan-1-one + 1,1′-(2′-(1H-pyrazol-1-yl)[1,1′:3′,1′′-terphenyl]-4,4′′-diyl)bis(ethan-1-one) (1041085-99-7)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; tetrabutylammonium acetate; Tri(p-tolyl)phosphine; at 120 ℃; for 24h; Inert atmosphere; Sealed tube; Schlenk technique;

DOI:10.1002/ejoc.201701022

Reference yield: 57.0%

1-phenylpyrazole (1126-00-7) + para-chloroacetophenone (99-91-2) → 1-(2′-(1H-pyrazol-1-yl)[1,1′-biphenyl]-4-yl)ethan-1-one + 1,1′-(2′-(1H-pyrazol-1-yl)[1,1′:3′,1′′-terphenyl]-4,4′′-diyl)bis(ethan-1-one) (1041085-99-7)

Guidance literature:

With [Ru(κ(P)-η6-{11-(diphenylphosphino)-12-phenyl-9,10-dihydro-9,10-ethanoanthracene})Cl2]; potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 36h;

DOI:10.1021/om200843f

Reference yield: 52.0%

1-phenylpyrazole (1126-00-7) + 4-acetophenyl triflate (109613-00-5) → 1-(2′-(1H-pyrazol-1-yl)[1,1′-biphenyl]-4-yl)ethan-1-one + 1,1′-(2′-(1H-pyrazol-1-yl)[1,1′:3′,1′′-terphenyl]-4,4′′-diyl)bis(ethan-1-one) (1041085-99-7)

Guidance literature:

With [RhCl₂(p-cymene)]2; potassium carbonate; In neat (no solvent); at 110 ℃; for 22h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1039/c9ob00806c

upstream raw materials:

1-phenylpyrazole

para-chloroacetophenone

1-(p-chlorophenyl)ethyl alcohol

para-bromoacetophenone