1-(tert-butyldimethylsiloxy)-4-methyl-6-phenyl-2-hexyn-3-yl methyl carbonate

Base Information

Chemical Name:1-(tert-butyldimethylsiloxy)-4-methyl-6-phenyl-2-hexyn-3-yl methyl carbonate
CAS No.:1082069-16-6
Molecular Formula:C₂₁H₃₂O₄Si
Molecular Weight:376.568
Hs Code.:

Synonyms:1-(tert-butyldimethylsiloxy)-4-methyl-6-phenyl-2-hexyn-3-yl methyl carbonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(tert-butyldimethylsiloxy)-4-methyl-6-phenyl-2-hexyn-3-yl methyl carbonate

Chemical Property:

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Technology Process of 1-(tert-butyldimethylsiloxy)-4-methyl-6-phenyl-2-hexyn-3-yl methyl carbonate

There total 2 articles about 1-(tert-butyldimethylsiloxy)-4-methyl-6-phenyl-2-hexyn-3-yl methyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1082069-21-3
C₁₉H₃₀O₂Si

: 79-22-1
methyl chloroformate

: 1082069-16-6
1-(tert-butyldimethylsiloxy)-4-methyl-6-phenyl-2-hexyn-3-yl methyl carbonate

Guidance literature:: C₁₉H₃₀O₂Si; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

methyl chloroformate; In tetrahydrofuran; hexane;
DOI:10.1021/ja806602h

Reference yield:

: 2550-26-7
4-Phenyl-2-butanone

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 1082069-16-6
1-(tert-butyldimethylsiloxy)-4-methyl-6-phenyl-2-hexyn-3-yl methyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 1 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 0 °C

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1021/acs.orglett.5b03615

Reference yield: 53.0%

: 1082069-16-6
1-(tert-butyldimethylsiloxy)-4-methyl-6-phenyl-2-hexyn-3-yl methyl carbonate

: 73183-34-3
bis(pinacol)diborane

: 1082069-34-8
4,4,5,5-tetramethyl-2-[1-(tert-butyldimethylsilanoxy)methyl-4-methyl-6-phenylpenta-2,3-dien-2-yl]-[1,3,2]dioxaborolane

Guidance literature:: With Cu(OC(CH₃)3); (CH₃)2C₁₃H₆O(P(C₆H₅)2)2; In tetrahydrofuran; reaction of boron compd. with 2 equiv. of acetylene deriv. in THF in presence of copper compd. and phosphine deriv. at 50°C for 1.5 h;
DOI:10.1021/ja806602h