N-{(Z)-2-bromo-3-[3-(1,3-dioxolan-2-yl)phenyl]prop-2-enyl}-N-(5-bromo-2-methylphenyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-{(Z)-2-bromo-3-[3-(1,3-dioxolan-2-yl)phenyl]prop-2-enyl}-N-(5-bromo-2-methylphenyl)-4-methylbenzenesulfonamide
• CAS No.: 1380159-40-9
• Molecular Formula: C₂₆H₂₅Br₂NO₄S
• Molecular Weight: 607.363
• Mol file: 1380159-40-9.mol

Synonyms:N-{(Z)-2-bromo-3-[3-(1,3-dioxolan-2-yl)phenyl]prop-2-enyl}-N-(5-bromo-2-methylphenyl)-4-methylbenzenesulfonamide

Chemical Property of N-{(Z)-2-bromo-3-[3-(1,3-dioxolan-2-yl)phenyl]prop-2-enyl}-N-(5-bromo-2-methylphenyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{(Z)-2-bromo-3-[3-(1,3-dioxolan-2-yl)phenyl]prop-2-enyl}-N-(5-bromo-2-methylphenyl)-4-methylbenzenesulfonamide

There total 5 articles about N-{(Z)-2-bromo-3-[3-(1,3-dioxolan-2-yl)phenyl]prop-2-enyl}-N-(5-bromo-2-methylphenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(5-bromo-2-methylphenyl)-4-methylbenzenesulfonamide + C12H13BrO3 → N-{(Z)-2-bromo-3-[3-(1,3-dioxolan-2-yl)phenyl]prop-2-enyl}-N-(5-bromo-2-methylphenyl)-4-methylbenzenesulfonamide (1380159-40-9)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In toluene; at 0 - 20 ℃; for 1h;

DOI:10.1002/chem.201103819

Reference yield:

3-[(Z)-2-bromo-3-hydroxyprop-1-enyl]benzaldehyde (1380159-39-6) → N-{(Z)-2-bromo-3-[3-(1,3-dioxolan-2-yl)phenyl]prop-2-enyl}-N-(5-bromo-2-methylphenyl)-4-methylbenzenesulfonamide (1380159-40-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; orthoformic acid triethyl ester / toluene / 5 h / 40 °C / Molecular sieve

2: triphenylphosphine; diethylazodicarboxylate / toluene / 1 h / 0 - 20 °C

With toluene-4-sulfonic acid; orthoformic acid triethyl ester; triphenylphosphine; diethylazodicarboxylate; In toluene;

DOI:10.1002/chem.201103819

Reference yield:

C11H9BrO3 → N-{(Z)-2-bromo-3-[3-(1,3-dioxolan-2-yl)phenyl]prop-2-enyl}-N-(5-bromo-2-methylphenyl)-4-methylbenzenesulfonamide (1380159-40-9)

Guidance literature:

Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / 0 °C

2: toluene-4-sulfonic acid; orthoformic acid triethyl ester / toluene / 5 h / 40 °C / Molecular sieve

3: triphenylphosphine; diethylazodicarboxylate / toluene / 1 h / 0 - 20 °C

With diisobutylaluminium hydride; toluene-4-sulfonic acid; orthoformic acid triethyl ester; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; toluene;

DOI:10.1002/chem.201103819

upstream raw materials:

3-[(Z)-2-bromo-3-hydroxyprop-1-enyl]benzaldehyde

5-bromo-2-methylaniline

p-toluenesulfonyl chloride

Downstream raw materials:

3-{(Z)-2-bromo-3-[N-(5-bromo-2-methylphenyl)-N-tosylamino]prop-1-enyl}benzoic acid

methyl 3-{(Z)-2-bromo-3-[N-(5-bromo-2-methylphenyl)-N-tosylamino]prop-1-enyl}benzoate

methyl 3-methyl-4-tosyl-4,5-dihydronaphto[3,2,1-cd]indole-8-carboxylate