(S)-2-Amino-N-[(R)-1-[(S)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-(1-formyl-1H-indol-3-yl)-ethyl]-3-(1H-imidazol-4-yl)-propionamide; hydrochloride

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Chemical Name:(S)-2-Amino-N-[(R)-1-[(S)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-(1-formyl-1H-indol-3-yl)-ethyl]-3-(1H-imidazol-4-yl)-propionamide; hydrochloride
CAS No.:126090-59-3
Molecular Formula:C₃₅H₃₇N₇O₄*ClH
Molecular Weight:656.184
Hs Code.:

(S)-2-Amino-N-[(R)-1-[(S)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-(1-formyl-1H-indol-3-yl)-ethyl]-3-(1H-imidazol-4-yl)-propionamide; hydrochloride

Synonyms:(S)-2-Amino-N-[(R)-1-[(S)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-(1-formyl-1H-indol-3-yl)-ethyl]-3-(1H-imidazol-4-yl)-propionamide; hydrochloride

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Chemical Property of (S)-2-Amino-N-[(R)-1-[(S)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-(1-formyl-1H-indol-3-yl)-ethyl]-3-(1H-imidazol-4-yl)-propionamide; hydrochloride

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Technology Process of (S)-2-Amino-N-[(R)-1-[(S)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-(1-formyl-1H-indol-3-yl)-ethyl]-3-(1H-imidazol-4-yl)-propionamide; hydrochloride

There total 12 articles about (S)-2-Amino-N-[(R)-1-[(S)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-(1-formyl-1H-indol-3-yl)-ethyl]-3-(1H-imidazol-4-yl)-propionamide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126089-22-3
Boc-His-D-Trp(CHO)-Phe-NMeBzl

: 126090-59-3
(S)-2-Amino-N-[(R)-1-[(S)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-(1-formyl-1H-indol-3-yl)-ethyl]-3-(1H-imidazol-4-yl)-propionamide; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 1.16667h;
DOI:10.1021/jm00095a013

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 126090-59-3
(S)-2-Amino-N-[(R)-1-[(S)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-(1-formyl-1H-indol-3-yl)-ethyl]-3-(1H-imidazol-4-yl)-propionamide; hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: N-methylmorpholine / CH₂Cl₂ / 0.33 h / -20 °C

2: CH₂Cl₂ / 2 h / -35 - 0 °C

3: 85.4 percent / anisole, HCl / dioxane; CH₂Cl₂ / 1.25 h / 0 - 20 °C

4: 86.7 percent / HOBT, 1-ethyl-3-<3-(N,N-dimethylamino)propyl>carbodiimide (WSCD) / dimethylformamide / 3 h / 0 - 20 °C

5: HCl / dioxane; CH₂Cl₂ / 1.17 h / 0 - 20 °C

6: N-methylmorpholine / dimethylformamide / 1 h / -15 °C

7: pyridine hydrochloride / dimethylformamide / 2 h / Ambient temperature

8: HCl / CH₂Cl₂; dioxane / 1.17 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; pyridine hydrochloride; benzotriazol-1-ol; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00095a013

Reference yield:

: 67729-36-6,60398-40-5
Boc-Phe-O-COO-isoBu

: 126090-59-3
(S)-2-Amino-N-[(R)-1-[(S)-1-(benzyl-methyl-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-(1-formyl-1H-indol-3-yl)-ethyl]-3-(1H-imidazol-4-yl)-propionamide; hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: CH₂Cl₂ / 2 h / -35 - 0 °C

2: 85.4 percent / anisole, HCl / dioxane; CH₂Cl₂ / 1.25 h / 0 - 20 °C

3: 86.7 percent / HOBT, 1-ethyl-3-<3-(N,N-dimethylamino)propyl>carbodiimide (WSCD) / dimethylformamide / 3 h / 0 - 20 °C

4: HCl / dioxane; CH₂Cl₂ / 1.17 h / 0 - 20 °C

5: N-methylmorpholine / dimethylformamide / 1 h / -15 °C

6: pyridine hydrochloride / dimethylformamide / 2 h / Ambient temperature

7: HCl / CH₂Cl₂; dioxane / 1.17 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; pyridine hydrochloride; benzotriazol-1-ol; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00095a013