Technology Process of Boc-His-D-Trp(CHO)-Phe-NMeBzl
There total 11 articles about Boc-His-D-Trp(CHO)-Phe-NMeBzl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine hydrochloride;
In
N,N-dimethyl-formamide;
for 2h;
Yield given;
Ambient temperature;
DOI:10.1021/jm00095a013
- Guidance literature:
-
Multi-step reaction with 7 steps
1: N-methylmorpholine / CH2Cl2 / 0.33 h / -20 °C
2: CH2Cl2 / 2 h / -35 - 0 °C
3: 85.4 percent / anisole, HCl / dioxane; CH2Cl2 / 1.25 h / 0 - 20 °C
4: 86.7 percent / HOBT, 1-ethyl-3-<3-(N,N-dimethylamino)propyl>carbodiimide (WSCD) / dimethylformamide / 3 h / 0 - 20 °C
5: HCl / dioxane; CH2Cl2 / 1.17 h / 0 - 20 °C
6: N-methylmorpholine / dimethylformamide / 1 h / -15 °C
7: pyridine hydrochloride / dimethylformamide / 2 h / Ambient temperature
With
4-methyl-morpholine; hydrogenchloride; pyridine hydrochloride; benzotriazol-1-ol; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00095a013
- Guidance literature:
-
Multi-step reaction with 6 steps
1: CH2Cl2 / 2 h / -35 - 0 °C
2: 85.4 percent / anisole, HCl / dioxane; CH2Cl2 / 1.25 h / 0 - 20 °C
3: 86.7 percent / HOBT, 1-ethyl-3-<3-(N,N-dimethylamino)propyl>carbodiimide (WSCD) / dimethylformamide / 3 h / 0 - 20 °C
4: HCl / dioxane; CH2Cl2 / 1.17 h / 0 - 20 °C
5: N-methylmorpholine / dimethylformamide / 1 h / -15 °C
6: pyridine hydrochloride / dimethylformamide / 2 h / Ambient temperature
With
4-methyl-morpholine; hydrogenchloride; pyridine hydrochloride; benzotriazol-1-ol; methoxybenzene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00095a013
