2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid tert-butyl ester diethyl ester

Base Information

Chemical Name:2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid tert-butyl ester diethyl ester
CAS No.:894778-83-7
Molecular Formula:C₂₆H₃₄NO₈P
Molecular Weight:519.532
Hs Code.:

Synonyms:2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid tert-butyl ester diethyl ester

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Chemical Property of 2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid tert-butyl ester diethyl ester

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Technology Process of 2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid tert-butyl ester diethyl ester

There total 2 articles about 2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid tert-butyl ester diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 116861-35-9
2-methylene-malonic acid tert-butyl ester ethyl ester

: 115961-49-4
[2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid

: 894778-83-7
2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid tert-butyl ester diethyl ester

Guidance literature:: [2-phenyl-1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid; With 1,1,1,3,3,3-hexamethyl-disilazane; at 110 ℃; for 1h;

2-methylene-malonic acid tert-butyl ester ethyl ester; at 110 ℃; for 3h;
DOI:10.1021/ol060575m

Reference yield:

: 32864-38-3
tert-Butyl ethyl malonate

: 894778-83-7
2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid tert-butyl ester diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 52 percent / acetic acid / Cu(OAc)2 / 3 h / Heating

2.1: 1,1,1,3,3,3-hexamethyldisilazane / 1 h / 110 °C

2.2: 62 percent / 3 h / 110 °C

With acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; copper diacetate; 1.1: Knoevenagel condensation;
DOI:10.1021/ol060575m