2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid monoethyl ester

Base Information

Chemical Name:2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid monoethyl ester
CAS No.:894778-86-0
Molecular Formula:C₂₂H₂₆NO₈P
Molecular Weight:463.424
Hs Code.:

Synonyms:2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid monoethyl ester

Suppliers and Price of 2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid monoethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid monoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid monoethyl ester

There total 6 articles about 2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid monoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 894778-83-7
2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid tert-butyl ester diethyl ester

: 894778-86-0
2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid monoethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol060575m

Reference yield: 63.0%

: 894778-80-4
(RS)-2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid diethyl ester

: 894778-86-0
2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid monoethyl ester

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃; for 48h;
DOI:10.1021/ol060575m

Reference yield:

: 32864-38-3
tert-Butyl ethyl malonate

: 894778-86-0
2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid monoethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 52 percent / acetic acid / Cu(OAc)2 / 3 h / Heating

2.1: 1,1,1,3,3,3-hexamethyldisilazane / 1 h / 110 °C

2.2: 62 percent / 3 h / 110 °C

3.1: 87 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid; copper diacetate; In dichloromethane; 1.1: Knoevenagel condensation;
DOI:10.1021/ol060575m