methyl 4-(2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate

Base Information

• Chemical Name: methyl 4-(2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate
• CAS No.: 1174044-37-1
• Molecular Formula: C₂₄H₂₉FN₂O₅
• Molecular Weight: 444.503

Synonyms:methyl 4-(2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate

Chemical Property of methyl 4-(2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate

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Technology Process of methyl 4-(2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate

There total 1 articles about methyl 4-(2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 2,5-dimethyl-1H-pyrrole-3-carboxylate (69687-80-5) + 2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetic acid chloride (1174044-36-0) → methyl 4-(2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (1174044-37-1)

Guidance literature:

methyl 2,5-dimethyl-1H-pyrrole-3-carboxylate; With aluminum (III) chloride; In DCM; at 0 ℃; for 0.166667h;

2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetic acid chloride; In dichloromethane; at 0 - 20 ℃;

Reference yield: 77.0%

methyl 4-(2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (1174044-37-1) + methyl iodide (74-88-4) → methyl 4-(2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetyl)-1,2,5-trimethyl-1H-pyrrole-3-carboxylate (1174044-38-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 58.4%

methyl 4-(2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate (1174044-37-1) → 4-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorobenzyl)-5,7-dimethyl-2,6-dihydro-1H-pyrrolo[3,4-d]pyridazin-1-one (1174043-77-6)

Guidance literature:

With hydrazine hydrate; acetic acid; at 20 ℃; for 48h;

upstream raw materials:

methyl 2,5-dimethyl-1H-pyrrole-3-carboxylate

2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetic acid chloride

Downstream raw materials:

methyl 4-(2-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorophenyl)acetyl)-1,2,5-trimethyl-1H-pyrrole-3-carboxylate

4-(3-(4-ethoxypiperidine-1-carbonyl)-4-fluorobenzyl)-5,7-dimethyl-2,6-dihydro-1H-pyrrolo[3,4-d]pyridazin-1-one

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