C₁₂H₁₆Br₂O₃

Base Information

• Chemical Name: C₁₂H₁₆Br₂O₃
• CAS No.: 1385058-11-6
• Molecular Formula: C₁₂H₁₆Br₂O₃
• Molecular Weight: 368.065
• Mol file: 1385058-11-6.mol

Synonyms:C₁₂H₁₆Br₂O₃

Chemical Property of C₁₂H₁₆Br₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₆Br₂O₃

There total 2 articles about C₁₂H₁₆Br₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,3-dibromophenol (57383-80-9) + Bromoacetaldehyde diethyl acetal (2032-35-1) → C12H16Br2O3 (1385058-11-6)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 95 ℃; for 12h;

DOI:10.1016/j.tetlet.2012.05.118

Reference yield:

3-Bromophenol (591-20-8) → C12H16Br2O3 (1385058-11-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / 48 h / 100 °C

2.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 1 h / -78 °C

2.2: 0.5 h / -78 - 20 °C

3.1: ethanol; sodium hydroxide / 3 h / Reflux

4.1: caesium carbonate / dimethyl sulfoxide / 12 h / 95 °C

With pyridine; ethanol; 2,2,6,6-tetramethylpiperidinyl-lithium; caesium carbonate; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1016/j.tetlet.2012.05.118

Reference yield:

C12H16Br2O3 (1385058-11-6) → C18H12O2 (1385058-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Amberlyst-15 / benzene / 8 h / Reflux

2: n-butyllithium / hexane; toluene / 0.25 h / -78 °C / Inert atmosphere

With n-butyllithium; In hexane; toluene; benzene; 2: Diels-Alder reaction;

DOI:10.1016/j.tetlet.2012.05.118

upstream raw materials:

3-Bromophenol

2,3-dibromophenol

Bromoacetaldehyde diethyl acetal

Downstream raw materials:

C₁₈H₁₂O₂

C₁₈H₁₂O₄S