6-(3,4-dimethoxyphenyl)-4-isobutoxy-5,6-dihydropyridin-2(1H)-one

Base Information

• Chemical Name: 6-(3,4-dimethoxyphenyl)-4-isobutoxy-5,6-dihydropyridin-2(1H)-one
• CAS No.: 1078052-84-2
• Molecular Formula: C₁₇H₂₃NO₄
• Molecular Weight: 305.374
• Mol file: 1078052-84-2.mol

Synonyms:6-(3,4-dimethoxyphenyl)-4-isobutoxy-5,6-dihydropyridin-2(1H)-one

Chemical Property of 6-(3,4-dimethoxyphenyl)-4-isobutoxy-5,6-dihydropyridin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(3,4-dimethoxyphenyl)-4-isobutoxy-5,6-dihydropyridin-2(1H)-one

There total 6 articles about 6-(3,4-dimethoxyphenyl)-4-isobutoxy-5,6-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H35NO7 (1078052-82-0) + C23H35NO7 (1078052-81-9) → 6-(3,4-dimethoxyphenyl)-4-isobutoxy-5,6-dihydropyridin-2(1H)-one (1078052-84-2) + C17H23NO4 (1078052-83-1)

Guidance literature:

C₂₃H₃₅NO₇; C₂₃H₃₅NO₇; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In methanol;

Reference yield:

Isobutyl bromide (78-77-3) + methyl 5-(tert-butoxycarbonylamino)-5-(3,4-dimethoxyphenyl)-3-oxopentanoate (1078052-80-8) → 6-(3,4-dimethoxyphenyl)-4-isobutoxy-5,6-dihydropyridin-2(1H)-one (1078052-84-2) + C17H23NO4 (1078052-83-1)

Guidance literature:

Isobutyl bromide; methyl 5-(tert-butoxycarbonylamino)-5-(3,4-dimethoxyphenyl)-3-oxopentanoate; With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetone; for 3h; Reflux;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With sodium hydrogencarbonate; In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2008.07.129

Reference yield:

3-amino-3-(3,4-dimethoxyphenyl)propanoic acid (34840-85-2,54160-62-2,34841-09-3,54160-63-3) → 6-(3,4-dimethoxyphenyl)-4-isobutoxy-5,6-dihydropyridin-2(1H)-one (1078052-84-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide / 24 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 48 h / 20 °C

3.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / acetone / 3 h / Reflux

3.2: 0.5 h / 20 °C

3.3: 24 h / 20 °C

With tetra-(n-butyl)ammonium iodide; potassium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; acetone;

upstream raw materials:

Isobutyl bromide

methyl 5-(tert-butoxycarbonylamino)-5-(3,4-dimethoxyphenyl)-3-oxopentanoate

C₂₃H₃₅NO₇

C₂₃H₃₅NO₇