(R)-5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-phenylsulfanyl-hexyl]-dihydro-furan-2-one

Base Information

Chemical Name:(R)-5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-phenylsulfanyl-hexyl]-dihydro-furan-2-one
CAS No.:159955-45-0
Molecular Formula:C₂₂H₃₆O₃SSi
Molecular Weight:408.678
Hs Code.:

Synonyms:(R)-5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-phenylsulfanyl-hexyl]-dihydro-furan-2-one

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Chemical Property of (R)-5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-phenylsulfanyl-hexyl]-dihydro-furan-2-one

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Technology Process of (R)-5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-phenylsulfanyl-hexyl]-dihydro-furan-2-one

There total 7 articles about (R)-5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-phenylsulfanyl-hexyl]-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 882-33-7
diphenyldisulfane

: 159955-44-9
(R)-5-[(S)-3-(tert-Butyl-dimethyl-silanyloxy)-6-hydroxy-hexyl]-dihydro-furan-2-one

: 159955-45-0
(R)-5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-phenylsulfanyl-hexyl]-dihydro-furan-2-one

Guidance literature:: With tributylphosphine; In pyridine; Ambient temperature;
DOI:10.1016/0040-4039(94)88291-6

Reference yield:

: 131722-62-8
1,2:5,6-dianhydro-3,4-dideoxy-erythro-hexitol

: 159955-45-0
(R)-5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-phenylsulfanyl-hexyl]-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 87 percent / CuI / tetrahydrofuran / -40 °C

2: 86 percent / NaH, Bu₄NBr / tetrahydrofuran / Ambient temperature

3: 100 percent / imidazole / dimethylformamide / Ambient temperature

4: 85 percent / OsO₄, NaIO₄, 10percent KHCO₃ / acetonitrile / Ambient temperature

5: 87 percent / H₂ / 10percent Pd-C / methanol

6: 67 percent / PDC / CH₂Cl₂ / Ambient temperature

7: 88 percent / NaBH₄ / ethanol / -30 °C

8: 97 percent / Bu₃P / pyridine / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; copper(l) iodide; osmium(VIII) oxide; dipyridinium dichromate; tributylphosphine; tetrabutylammomium bromide; hydrogen; sodium hydride; potassium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/0040-4039(94)88291-6

Reference yield:

: 159955-38-1
(5S,8S)-Dodeca-1,11-diene-5,8-diol

: 159955-45-0
(R)-5-[(R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-phenylsulfanyl-hexyl]-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / NaH, Bu₄NBr / tetrahydrofuran / Ambient temperature

2: 100 percent / imidazole / dimethylformamide / Ambient temperature

3: 85 percent / OsO₄, NaIO₄, 10percent KHCO₃ / acetonitrile / Ambient temperature

4: 87 percent / H₂ / 10percent Pd-C / methanol

5: 67 percent / PDC / CH₂Cl₂ / Ambient temperature

6: 88 percent / NaBH₄ / ethanol / -30 °C

7: 97 percent / Bu₃P / pyridine / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; dipyridinium dichromate; tributylphosphine; tetrabutylammomium bromide; hydrogen; sodium hydride; potassium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/0040-4039(94)88291-6