5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole
CAS No.:1567711-31-2
Molecular Formula:C₂₇H₂₇F₃N₂O₃Si
Molecular Weight:512.604
Hs Code.:

Synonyms:5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

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Chemical Property of 5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

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Technology Process of 5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

There total 7 articles about 5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1087782-00-0,1136832-69-3
(Z)-N′-hydroxy-4-(4-(trifluoromethyl)phenoxy)benzimidamide

: 90446-67-6
4-((tert-butyldimethylsilyl)oxy)benzoyl chloride

: 1567711-31-2
5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

Guidance literature:: In toluene; at 120 ℃; for 27h;
DOI:10.1021/ja500053x

Reference yield:

: 402-45-9
4-hydroxybenzotrifluoride

: 1567711-31-2
5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethylglycine hydrochoride; caesium carbonate; copper(l) iodide / 1,4-dioxane / 140 h / 90 °C / Inert atmosphere

2: hydroxylamine / ethanol / 1 h / Reflux

3: toluene / 27 h / 120 °C

With copper(l) iodide; hydroxylamine; N,N-dimethylglycine hydrochoride; caesium carbonate; In 1,4-dioxane; ethanol; toluene;
DOI:10.1021/ja500053x

Reference yield:

: 78324-14-8
tert-butyldimethylsilyl 4-((tert-butyldimethylsilyl)oxy)benzoate

: 1567711-31-2
5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-(4-(trifluoromethyl)phenoxy)-phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3.5 h / 0 - 20 °C

2: toluene / 27 h / 120 °C

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja500053x