Chemical Property of Abt-751
Chemical Property:
- Vapor Pressure:9.51E-13mmHg at 25°C
- Melting Point:162 °C(dec.)
- Refractive Index:1.676
- Boiling Point:551 °C at 760 mmHg
- PKA:7.86±0.40(Predicted)
- Flash Point:287 °C
- PSA：108.93000
- Density:1.427 g/cm3
- LogP:4.56700
- Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
- Solubility.:insoluble in H2O; ≥18.55 mg/mL in DMSO; ≥25.53 mg/mL in EtOH with ultrasonic
- XLogP3:2.8
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:6
- Exact Mass:371.09397721
- Heavy Atom Count:26
- Complexity:523
- Purity/Quality:
-
99%, *data from raw suppliers
ABT751 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O
- Recent ClinicalTrials:ABT-751 With Chemotherapy for Relapsed Pediatric ALL
- Recent EU Clinical Trials:A Phase 2 Study Evaluating the Safety and Efficacy of ABT-751 in Combination with Docetaxel Versus Docetaxel Alone in Subjects with Advanced or Metastatic Non-Small Cell Lung Cancer
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Description
ABT-751 is a tubulin polymerization inhibitor that binds to the colchicine binding site on β-tubulin (Ki = 3.3 μM). It inhibits tubulin polymerization in a concentration-dependent manner and inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 μg/ml). ABT-751 (100 mg/kg, p.o.) induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models. It also induces tumor endothelial cell retraction and reduces tumor perfusion, but not muscle perfusion, in a 9L rat glioma subcutaneous tumor model.
