[2-(1r,4r)-4-(2-chloro-8-oxo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7,8-dihydro-9H-purin-9-yl)cyclohexyl]acetonitrile

Base Information

Chemical Name:[2-(1r,4r)-4-(2-chloro-8-oxo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7,8-dihydro-9H-purin-9-yl)cyclohexyl]acetonitrile
CAS No.:1414805-50-7
Molecular Formula:C₁₉H₂₈ClN₅O₂Si
Molecular Weight:422.002
Hs Code.:

Synonyms:[2-(1r,4r)-4-(2-chloro-8-oxo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7,8-dihydro-9H-purin-9-yl)cyclohexyl]acetonitrile

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Chemical Property of [2-(1r,4r)-4-(2-chloro-8-oxo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7,8-dihydro-9H-purin-9-yl)cyclohexyl]acetonitrile

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Technology Process of [2-(1r,4r)-4-(2-chloro-8-oxo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7,8-dihydro-9H-purin-9-yl)cyclohexyl]acetonitrile

There total 7 articles about [2-(1r,4r)-4-(2-chloro-8-oxo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7,8-dihydro-9H-purin-9-yl)cyclohexyl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1414805-53-0
[2-(1r,4r)-4-(2-chloro-8-oxo-7,8-dihydro-9H-purin-9-yl)cyclohexyl]acetonitrile

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1414805-50-7
[2-(1r,4r)-4-(2-chloro-8-oxo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7,8-dihydro-9H-purin-9-yl)cyclohexyl]acetonitrile

Guidance literature:: [2-(1r,4r)-4-(2-chloro-8-oxo-7,8-dihydro-9H-purin-9-yl)cyclohexyl]acetonitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b00533

Reference yield: 83.0%

: 1414805-50-7
[2-(1r,4r)-4-(2-chloro-8-oxo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7,8-dihydro-9H-purin-9-yl)cyclohexyl]acetonitrile

Guidance literature:

Reference yield:

: 1313279-47-8
trans-(4-cyanomethyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1414805-50-7
[2-(1r,4r)-4-(2-chloro-8-oxo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7,8-dihydro-9H-purin-9-yl)cyclohexyl]acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C / Inert atmosphere

3.1: tin(II) chloride dihdyrate / ethanol / 3 h / 80 °C / Sealed tube

4.1: acetonitrile / 3 h / 80 °C / Sealed tube

5.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

5.2: 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; tin(II) chloride dihdyrate; sodium hydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/acs.jmedchem.9b00533