((1r,4r)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzene-sulfonate

Base Information

• Chemical Name: ((1r,4r)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzene-sulfonate
• CAS No.: 947141-76-6
• Molecular Formula: C₁₉H₂₉NO₅S
• Molecular Weight: 383.509
• Mol file: 947141-76-6.mol

Synonyms:((1r,4r)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzene-sulfonate

Chemical Property of ((1r,4r)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzene-sulfonate

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1r,4r)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzene-sulfonate

There total 6 articles about ((1r,4r)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzene-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester (239074-29-4) + p-toluenesulfonyl chloride (98-59-9) → ((1r,4r)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzene-sulfonate (947141-76-6)

Guidance literature:

trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester; p-toluenesulfonyl chloride; With triethylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃;

With dmap; In tetrahydrofuran; dichloromethane; for 2h;

Reference yield: 83.0%

p-toluenesulfonyl chloride (98-59-9) + tert-butyl ((cis)-4-(hydroxymethyl)cyclohexyl)carbamate (223131-01-9) → ((1r,4r)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzene-sulfonate (947141-76-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → ((1r,4r)-4-(tert-butoxycarbonylamino)cyclohexyl)methyl 4-methylbenzene-sulfonate (947141-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 °C

2: triethylamine / dichloromethane / 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester

p-toluenesulfonyl chloride

di-tert-butyl dicarbonate

((1R,4R)-4-aminocyclohexyl)methanol

Downstream raw materials:

C₂₈H₃₈N₈O₅

trans-(4-cyanomethyl-cyclohexyl)-carbamic acid tert-butyl ester

tert-butyl (1R,4R)-4-((2-chloro-6a,7,9,10-tetrahydro-[1,4]oxazin[3,4-h]pteridin-5(6H)-yl)methyl)cyclohexylcarbamate

2-((1r,4r)-4-(2-(2-methoxypyridin-3-ylamino)-5-nitropyrimidin-4-ylamino)cyclohexyl)acetonitrile