1,1-dimethylethyl 4-[({[5-(aminocarbonyl)-2,4-difluorophenyl]amino}carbonyl)(3-fluorophenyl)amino]-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-[({[5-(aminocarbonyl)-2,4-difluorophenyl]amino}carbonyl)(3-fluorophenyl)amino]-1-piperidinecarboxylate
CAS No.:1150100-37-0
Molecular Formula:C₂₄H₂₇F₃N₄O₄
Molecular Weight:492.498
Hs Code.:

Synonyms:1,1-dimethylethyl 4-[({[5-(aminocarbonyl)-2,4-difluorophenyl]amino}carbonyl)(3-fluorophenyl)amino]-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-[({[5-(aminocarbonyl)-2,4-difluorophenyl]amino}carbonyl)(3-fluorophenyl)amino]-1-piperidinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-[({[5-(aminocarbonyl)-2,4-difluorophenyl]amino}carbonyl)(3-fluorophenyl)amino]-1-piperidinecarboxylate

There total 1 articles about 1,1-dimethylethyl 4-[({[5-(aminocarbonyl)-2,4-difluorophenyl]amino}carbonyl)(3-fluorophenyl)amino]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1150100-36-9
5-({[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)(3-fluorophenyl)amino]carbonyl}amino)-2,4-difluorobenzoic acid

: 1150100-37-0
1,1-dimethylethyl 4-[({[5-(aminocarbonyl)-2,4-difluorophenyl]amino}carbonyl)(3-fluorophenyl)amino]-1-piperidinecarboxylate

Guidance literature:: 5-({[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)(3-fluorophenyl)amino]carbonyl}amino)-2,4-difluorobenzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

With ammonia; In water; N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield: 89.0%

: 1150100-37-0
1,1-dimethylethyl 4-[({[5-(aminocarbonyl)-2,4-difluorophenyl]amino}carbonyl)(3-fluorophenyl)amino]-1-piperidinecarboxylate

: 1150100-38-1
2,4-difluoro-5-({[(3-fluorophenyl)(4-piperidinyl)amino]carbonyl}amino)benzamide

Guidance literature:: 1,1-dimethylethyl 4-[({[5-(aminocarbonyl)-2,4-difluorophenyl]amino}carbonyl)(3-fluorophenyl)amino]-1-piperidinecarboxylate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

With sodium hydroxide; In water; pH=8;