5-({[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)(3-fluorophenyl)amino]carbonyl}amino)-2,4-difluorobenzoic acid

Base Information

Chemical Name:5-({[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)(3-fluorophenyl)amino]carbonyl}amino)-2,4-difluorobenzoic acid
CAS No.:1150100-36-9
Molecular Formula:C₂₄H₂₆F₃N₃O₅
Molecular Weight:493.483
Hs Code.:

Synonyms:5-({[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)(3-fluorophenyl)amino]carbonyl}amino)-2,4-difluorobenzoic acid

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Chemical Property of 5-({[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)(3-fluorophenyl)amino]carbonyl}amino)-2,4-difluorobenzoic acid

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Technology Process of 5-({[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)(3-fluorophenyl)amino]carbonyl}amino)-2,4-difluorobenzoic acid

There total 1 articles about 5-({[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)(3-fluorophenyl)amino]carbonyl}amino)-2,4-difluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1150100-35-8
1,1-dimethylethyl 4-[[({2,4-difluoro-5-[(methyloxy)carbonyl]phenyl}amino)carbonyl](3-fluorophenyl)amino]-1-piperidinecarboxylate

: 1150100-36-9
5-({[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)(3-fluorophenyl)amino]carbonyl}amino)-2,4-difluorobenzoic acid

Guidance literature:: 1,1-dimethylethyl 4-[[({2,4-difluoro-5-[(methyloxy)carbonyl]phenyl}amino)carbonyl](3-fluorophenyl)amino]-1-piperidinecarboxylate; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 72h;

With hydrogenchloride; In water; pH=3;

Reference yield: 88.0%

: 1150100-36-9
5-({[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)(3-fluorophenyl)amino]carbonyl}amino)-2,4-difluorobenzoic acid

: 1150100-37-0
1,1-dimethylethyl 4-[({[5-(aminocarbonyl)-2,4-difluorophenyl]amino}carbonyl)(3-fluorophenyl)amino]-1-piperidinecarboxylate

Guidance literature:: 5-({[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)(3-fluorophenyl)amino]carbonyl}amino)-2,4-difluorobenzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

With ammonia; In water; N,N-dimethyl-formamide; at 20 ℃; for 4h;