N,N'-bis(benzyloxycarbonyl)-N''-4-hydroxybenzylguanidine

Base Information

• Chemical Name: N,N'-bis(benzyloxycarbonyl)-N''-4-hydroxybenzylguanidine
• CAS No.: 188922-39-6
• Molecular Formula: C₂₄H₂₃N₃O₅
• Molecular Weight: 433.464
• Mol file: 188922-39-6.mol

Synonyms:N,N'-bis(benzyloxycarbonyl)-N''-4-hydroxybenzylguanidine

Chemical Property of N,N'-bis(benzyloxycarbonyl)-N''-4-hydroxybenzylguanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-bis(benzyloxycarbonyl)-N''-4-hydroxybenzylguanidine

There total 5 articles about N,N'-bis(benzyloxycarbonyl)-N''-4-hydroxybenzylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-hydroxy-benzylamine hydrochloride (1004-23-5) + N,N'-dibenzyloxycarbonyl-(S)-methyl-isothiourea (25508-20-7) → N,N'-bis(benzyloxycarbonyl)-N''-4-hydroxybenzylguanidine (188922-39-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm061398y

Reference yield:

C29H31N3O6 (1026945-77-6) → N,N'-bis(benzyloxycarbonyl)-N''-4-hydroxybenzylguanidine (188922-39-6)

Guidance literature:

With toluene-4-sulfonic acid; In methanol;

DOI:10.1248/cpb.46.846

Reference yield:

4-cyanophenol (767-00-0) → N,N'-bis(benzyloxycarbonyl)-N''-4-hydroxybenzylguanidine (188922-39-6)

Guidance literature:

Multi-step reaction with 4 steps

1: p-TsOH*H₂O / benzene

2: LiAlH₄ / tetrahydrofuran

3: tetrahydrofuran

4: p-TsOH*H₂O / methanol

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; benzene;

DOI:10.1248/cpb.46.846

upstream raw materials:

C₂₉H₃₁N₃O₆

4-hydroxy-benzylamine hydrochloride

N,N'-dibenzyloxycarbonyl-(S)-methyl-isothiourea

4-cyanophenol

Downstream raw materials:

C₃₂H₃₆N₄O₈