4-(2-amino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

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Chemical Name:4-(2-amino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide
CAS No.:1454656-55-3
Molecular Formula:C₁₉H₁₅F₃N₆O
Molecular Weight:400.363
Hs Code.:

Synonyms:4-(2-amino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

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Chemical Property of 4-(2-amino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

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Technology Process of 4-(2-amino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

There total 7 articles about 4-(2-amino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454656-81-5
4-(2-methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide

: 1454656-55-3
4-(2-amino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

Guidance literature:: 4-(2-methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide; With Oxone; In tetrahydrofuran; water; at 20 ℃; for 16h;

With ammonium hydroxide; In 1,4-dioxane; at 90 - 100 ℃; for 33h; Sealed tube;

Reference yield:

: 30766-03-1
4-bromo-2-picolinic acid

: 1454656-55-3
4-(2-amino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.17 h

1.2: 21 h / 20 °C

2.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; caesium carbonate / toluene / 7 h / 100 °C

3.1: Oxone / tetrahydrofuran; water / 16 h / 20 °C

3.2: 33 h / 90 - 100 °C / Sealed tube

With 4-methyl-morpholine; Oxone; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; HATU; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1454657-40-9
4-bromo-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

: 1454656-55-3
4-(2-amino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; caesium carbonate / toluene / 7 h / 100 °C

2.1: Oxone / tetrahydrofuran; water / 16 h / 20 °C

2.2: 33 h / 90 - 100 °C / Sealed tube

With Oxone; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; water; toluene;