4-(2-methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide

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Chemical Name:4-(2-methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide
CAS No.:1454656-81-5
Molecular Formula:C₂₀H₁₆F₃N₅OS
Molecular Weight:431.441
Hs Code.:

Synonyms:4-(2-methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide

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Chemical Property of 4-(2-methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide

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Technology Process of 4-(2-methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide

There total 5 articles about 4-(2-methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 916059-20-6
2-(methylthio)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine

: 1454657-40-9
4-bromo-N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

: 1454656-81-5
4-(2-methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 7h;

Reference yield:

: 30766-03-1
4-bromo-2-picolinic acid

: 1454656-81-5
4-(2-methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.17 h

1.2: 21 h / 20 °C

2.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; caesium carbonate / toluene / 7 h / 100 °C

With 4-methyl-morpholine; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; HATU; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 365996-86-7
tert-Butyl 2-(methylsulfanyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate

: 1454656-81-5
4-(2-methylsulfanyl-5,7-dihydro-pyrrolo[3,4-d]pyrimidin-6-yl)-pyridine-2-carboxylic acid (3-trifluoromethyl-phenyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; caesium carbonate / toluene / 7 h / 100 °C

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In dichloromethane; toluene;