methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-14-oxo-tetradeca-5Z,12E-dienoate

Base Information

Chemical Name:methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-14-oxo-tetradeca-5Z,12E-dienoate
CAS No.:75879-50-4
Molecular Formula:C₃₄H₄₆O₆Si
Molecular Weight:578.821
Hs Code.:

Synonyms:methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-14-oxo-tetradeca-5Z,12E-dienoate

Suppliers and Price of methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-14-oxo-tetradeca-5Z,12E-dienoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-14-oxo-tetradeca-5Z,12E-dienoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-14-oxo-tetradeca-5Z,12E-dienoate

There total 14 articles about methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-14-oxo-tetradeca-5Z,12E-dienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 74581-59-2
methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-12-oxo-dodeca-5Z-enoate

: 2136-75-6
(triphenylphosphoranylidene)acetaldehyde

: 75879-50-4
methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-14-oxo-tetradeca-5Z,12E-dienoate

Guidance literature:: In N,N-dimethyl-formamide; for 20h; Ambient temperature;

Reference yield:

: 72605-81-3
1,2-O-isopropylidene-3-O-(methylthio)thiocarbonyl-α-D-glucofuranose

: 75879-50-4
methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-14-oxo-tetradeca-5Z,12E-dienoate

Guidance literature:: Multi-step reaction with 12 steps

1: 4-dimethylaminopyridine / diethyl ether / 1.5 h / Ambient temperature

2: tributyltin hydride / toluene / 16 h / Heating

3: 0.02 M methanolic sodium methoxide / 2 h / Ambient temperature

4: 1.) p-toluenesulfonyl chloride, pyridine, 2.) 1.17 N aq. KOH / 1.) CHCl₃, -50 deg C, 3 h; room temperature, 20 h, 2.) MeOH

5: n-BuLi / hexamethylphosphoric acid triamide / 20 h / Ambient temperature

6: diethyl ether

7: hydrogen, ethylene diamine / nickel acetate/sodium borohydride / ethanol

8: imidazole / dimethylformamide / 17 h / 78 °C

9: zinc chloride / 1 h / -10 °C

10: p-toluenesulfonic acid / acetone / 1 h / Ambient temperature

11: mercuric oxide, mercuric chloride / acetone; H₂O / 8 h / Ambient temperature

12: 90 percent / dimethylformamide / 20 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; potassium hydroxide; n-butyllithium; hydrogen; tri-n-butyl-tin hydride; sodium methylate; toluene-4-sulfonic acid; ethylenediamine; p-toluenesulfonyl chloride; mercury dichloride; mercury(II) oxide; zinc(II) chloride; sodium tetrahydroborate; nickel diacetate; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 4005-46-3,4494-96-6,22248-87-9,142941-40-0
3-deoxy-1,2-O-isopropylidene-D-glucose

: 75879-50-4
methyl 8R-tert-butyldiphenylsilyloxy-9S,11R-dihydroxy-9,11-O-isopropylidene-14-oxo-tetradeca-5Z,12E-dienoate

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) p-toluenesulfonyl chloride, pyridine, 2.) 1.17 N aq. KOH / 1.) CHCl₃, -50 deg C, 3 h; room temperature, 20 h, 2.) MeOH

2: n-BuLi / hexamethylphosphoric acid triamide / 20 h / Ambient temperature

3: diethyl ether

4: hydrogen, ethylene diamine / nickel acetate/sodium borohydride / ethanol

5: imidazole / dimethylformamide / 17 h / 78 °C

6: zinc chloride / 1 h / -10 °C

7: p-toluenesulfonic acid / acetone / 1 h / Ambient temperature

8: mercuric oxide, mercuric chloride / acetone; H₂O / 8 h / Ambient temperature

9: 90 percent / dimethylformamide / 20 h / Ambient temperature

With pyridine; 1H-imidazole; potassium hydroxide; n-butyllithium; hydrogen; toluene-4-sulfonic acid; ethylenediamine; p-toluenesulfonyl chloride; mercury dichloride; mercury(II) oxide; zinc(II) chloride; sodium tetrahydroborate; nickel diacetate; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetone;