4-(4-fluorotetrahydro-2H-pyran-4-yl)-N'-hydroxybenzenecarboximide amide

Base Information

Chemical Name:4-(4-fluorotetrahydro-2H-pyran-4-yl)-N'-hydroxybenzenecarboximide amide
CAS No.:1085453-58-2
Molecular Formula:C₁₂H₁₅FN₂O₂
Molecular Weight:238.262
Hs Code.:

Synonyms:4-(4-fluorotetrahydro-2H-pyran-4-yl)-N'-hydroxybenzenecarboximide amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-fluorotetrahydro-2H-pyran-4-yl)-N'-hydroxybenzenecarboximide amide

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Technology Process of 4-(4-fluorotetrahydro-2H-pyran-4-yl)-N'-hydroxybenzenecarboximide amide

There total 5 articles about 4-(4-fluorotetrahydro-2H-pyran-4-yl)-N'-hydroxybenzenecarboximide amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1085453-58-2
4-(4-fluorotetrahydro-2H-pyran-4-yl)-N'-hydroxybenzenecarboximide amide

Guidance literature:

Reference yield: 76.0%

: 1085453-57-1
4-(4-fluorotetrahydro-2H-pyran-4-yl)benzenecarbonitrile

: 1085453-58-2
4-(4-fluorotetrahydro-2H-pyran-4-yl)-N'-hydroxybenzenecarboximide amide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In ethanol; for 4h; Heating / reflux;

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 1085453-58-2
4-(4-fluorotetrahydro-2H-pyran-4-yl)-N'-hydroxybenzenecarboximide amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran; diethyl ether / 1.5 h / -40 °C

1.2: 2.67 h / -78 - 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 0.5 h / -78 °C

2.2: -20 - 20 °C

3.1: hydroxylamine hydrochloride; triethylamine / ethanol / 4 h / Heating / reflux

With diethylamino-sulfur trifluoride; hydroxylamine hydrochloride; isopropylmagnesium chloride; triethylamine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;