5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazole-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazole-4-carboxylic acid methyl ester
• CAS No.: 1422175-45-8
• Molecular Formula: C₁₂H₁₁FN₂O₂S
• Molecular Weight: 266.296
• Mol file: 1422175-45-8.mol

Synonyms:5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazole-4-carboxylic acid methyl ester

Chemical Property of 5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazole-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazole-4-carboxylic acid methyl ester

There total 4 articles about 5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxylic acid methyl ester (93103-04-9) + methyl iodide (74-88-4) → 5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazole-4-carboxylic acid methyl ester (1422175-45-8)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 2h;

Reference yield:

methyl 4-fluorobenzoyl acetate (63131-29-3) → 5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazole-4-carboxylic acid methyl ester (1422175-45-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium nitrite; acetic acid / water / 17 h / 10 - 20 °C

2: 5%-palladium/activated carbon; hydrogen; hydrogenchloride / water; methanol / 20 °C

3: N,N-dimethyl-formamide / 3 h / 95 °C

4: potassium carbonate / methanol / 2 h / 20 °C

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; potassium carbonate; acetic acid; sodium nitrite; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

3-(4-fluorophenyl)-2-hydroxyimino-3-oxo-propionic acid methyl ester (1422175-44-7) → 5-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazole-4-carboxylic acid methyl ester (1422175-45-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 5%-palladium/activated carbon; hydrogen; hydrogenchloride / water; methanol / 20 °C

2: N,N-dimethyl-formamide / 3 h / 95 °C

3: potassium carbonate / methanol / 2 h / 20 °C

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; potassium carbonate; In methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

5-(4-fluorophenyl)-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxylic acid methyl ester

methyl iodide

methyl 4-fluorobenzoyl acetate

3-(4-fluorophenyl)-2-hydroxyimino-3-oxo-propionic acid methyl ester

Downstream raw materials:

C₁₂H₁₁FN₂O₃S

C₂₅H₂₂FN₅O₅S

C₂₈H₂₄FN₇O₃S

5-(4-fluorophenyl)-2-methylthio-1H-imidazole-4-carboxylic acid