(2R,4R,5S)-1-(benzyloxy)-5-<(tert-butyloxycarbonyl)amino>-4-hydroxy-2,7-dimethyloctane

Base Information

Chemical Name:(2R,4R,5S)-1-(benzyloxy)-5-<(tert-butyloxycarbonyl)amino>-4-hydroxy-2,7-dimethyloctane
CAS No.:89065-03-2
Molecular Formula:C₂₂H₃₇NO₄
Molecular Weight:379.54
Hs Code.:

Synonyms:(2R,4R,5S)-1-(benzyloxy)-5-<(tert-butyloxycarbonyl)amino>-4-hydroxy-2,7-dimethyloctane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R,5S)-1-(benzyloxy)-5-<(tert-butyloxycarbonyl)amino>-4-hydroxy-2,7-dimethyloctane

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Technology Process of (2R,4R,5S)-1-(benzyloxy)-5-<(tert-butyloxycarbonyl)amino>-4-hydroxy-2,7-dimethyloctane

There total 4 articles about (2R,4R,5S)-1-(benzyloxy)-5-<(tert-butyloxycarbonyl)amino>-4-hydroxy-2,7-dimethyloctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63930-49-4
(R)-3-(benzyloxy)-2-methylpropan-1-ol

: 89065-03-2
(2R,4R,5S)-1-(benzyloxy)-5-<(tert-butyloxycarbonyl)amino>-4-hydroxy-2,7-dimethyloctane

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / PPh₃, NBS / CH₂Cl₂ / 15 h / Ambient temperature

2: 1.) Mg, I₂ / 1.) THF, 12 h, 2.) THF, RT, 3.5 h

With N-Bromosuccinimide; iodine; magnesium; triphenylphosphine; In dichloromethane;

Reference yield:

: 17690-16-3
benzyl bromomethyl ether

: 89065-03-2
(2R,4R,5S)-1-(benzyloxy)-5-<(tert-butyloxycarbonyl)amino>-4-hydroxy-2,7-dimethyloctane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LiN(Me₃Si)2 / 1.) THF, -78 deg C, 0.5 h, 2.) THF, from -78 deg C to 0 deg C, 5.5 h

2: 85 percent / Ca(BH₄)2 / ethanol; tetrahydrofuran / 0 °C

3: 78 percent / PPh₃, NBS / CH₂Cl₂ / 15 h / Ambient temperature

4: 1.) Mg, I₂ / 1.) THF, 12 h, 2.) THF, RT, 3.5 h

With N-Bromosuccinimide; calcium borohydride; iodine; magnesium; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 80697-96-7,105943-88-2
(4S,5S)-3-<3-(benzyloxy)-2-methylpropionyl>-4-methyl-5-phenyl-1-oxazolidinone

: 89065-03-2
(2R,4R,5S)-1-(benzyloxy)-5-<(tert-butyloxycarbonyl)amino>-4-hydroxy-2,7-dimethyloctane

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / Ca(BH₄)2 / ethanol; tetrahydrofuran / 0 °C

2: 78 percent / PPh₃, NBS / CH₂Cl₂ / 15 h / Ambient temperature

3: 1.) Mg, I₂ / 1.) THF, 12 h, 2.) THF, RT, 3.5 h

With N-Bromosuccinimide; calcium borohydride; iodine; magnesium; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane;