(4E)-4-benzylidene-3-phenyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one

Base Information

Chemical Name:(4E)-4-benzylidene-3-phenyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one
CAS No.:1388624-58-5
Molecular Formula:C₂₃H₁₆F₃NO
Molecular Weight:379.381
Hs Code.:

Synonyms:(4E)-4-benzylidene-3-phenyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one

Suppliers and Price of (4E)-4-benzylidene-3-phenyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4E)-4-benzylidene-3-phenyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one

Chemical Property:

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Technology Process of (4E)-4-benzylidene-3-phenyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one

There total 4 articles about (4E)-4-benzylidene-3-phenyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1388624-38-1
benzaldehyde O-{1-phenyl-3-[4-(trifluoromethyl)phenyl]prop-2-yn-1-yl}oxime

: 1388624-58-5
(4E)-4-benzylidene-3-phenyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one

Guidance literature:: With copper(I) bromide; In toluene; at 100 ℃; for 16h; regioselective reaction; Inert atmosphere;
DOI:10.1055/s-0031-1290819

Reference yield:

: 1228682-63-0
1-phenyl-3-(4-(trifluoromethyl)phenyl)prop-2-yn-1-ol

: 1388624-58-5
(4E)-4-benzylidene-3-phenyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: hydrazine hydrate / tetrahydrofuran / 1 h / 20 °C

3: tetrahydrofuran / 2 h / 65 °C

4: copper(I) bromide / toluene / 16 h / 100 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; copper(I) bromide; In tetrahydrofuran; toluene; 1: Mitsunobu reaction;
DOI:10.1055/s-0031-1290819

Reference yield:

: 1228682-68-5
C₁₆H₁₂F₃NO

: 1388624-58-5
(4E)-4-benzylidene-3-phenyl-1-[4-(trifluoromethyl)phenyl]azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / 65 °C

2: copper(I) bromide / toluene / 16 h / 100 °C / Inert atmosphere

With copper(I) bromide; In tetrahydrofuran; toluene;
DOI:10.1055/s-0031-1290819