(Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Base Information

Chemical Name:(Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid
CAS No.:1333154-08-7
Molecular Formula:C₁₃H₁₀F₃N₃O₃
Molecular Weight:313.236
Hs Code.:

Synonyms:(Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

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Chemical Property of (Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

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Technology Process of (Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

There total 5 articles about (Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333151-73-7
propan-2-yl (Z)-3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoate

: 1333154-08-7
(Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Guidance literature:: propan-2-yl (Z)-3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]prop-2-enoate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water; Cooling with ice;

Reference yield:

: 868167-61-7
3-methoxy-5-(trifluoromethyl)benzonitrile

: 1333154-08-7
(Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium(II) chloride hexahydrate; sodium monohydrogen sulfide x-hydrate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: diethyl ether / 12 h / 20 °C

3.1: N,N-dimethyl-formamide / 2 h / 90 °C

4.1: triethylamine / dichloromethane / 0.5 h / 15 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

5.2: Cooling with ice

With sodium monohydrogen sulfide x-hydrate; magnesium(II) chloride hexahydrate; water; triethylamine; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1251940-10-9
C₉H₈F₃NOS

: 1333154-08-7
(Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl ether / 12 h / 20 °C

2.1: N,N-dimethyl-formamide / 2 h / 90 °C

3.1: triethylamine / dichloromethane / 0.5 h / 15 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

4.2: Cooling with ice

With water; triethylamine; lithium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;