3-Methoxy-5-trifluroMethyl benzonitrile

Base Information

• Chemical Name: 3-Methoxy-5-trifluroMethyl benzonitrile
• CAS No.: 868167-61-7
• Molecular Formula: C₉H₆F₃NO
• Molecular Weight: 201.148
• Hs Code.: 2926907090
• Mol file: 868167-61-7.mol

Synonyms:3-methoxy-5-(trifluoromethyl)benzonitrile

Chemical Property of 3-Methoxy-5-trifluroMethyl benzonitrile

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

3-Methoxy-5-(trifluoromethyl)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methoxy-5-trifluroMethyl benzonitrile

There total 5 articles about 3-Methoxy-5-trifluroMethyl benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-iodo-3-methoxy-5-(trifluoromethyl)benzene (868167-60-6) + copper(I) cyanide (544-92-3) → 3-methoxy-5-(trifluoromethyl)benzonitrile (868167-61-7)

Guidance literature:

With tert.-butylnitrite; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 24h;

Reference yield:

1-iodo-3-methoxy-5-(trifluoromethyl)benzene (868167-60-6) + copper(l) cyanide → 3-methoxy-5-(trifluoromethyl)benzonitrile (868167-61-7)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 24h;

Reference yield:

5-(trifluoromethyl)-m-anisidine (349-55-3) → 3-methoxy-5-(trifluoromethyl)benzonitrile (868167-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / water; tetrahydrofuran / 1 h / 20 °C

1.2: 0 - 20 °C

2.1: N,N-dimethyl-formamide / 24 h / 100 °C

With hydrogenchloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;

upstream raw materials:

1-iodo-3-methoxy-5-(trifluoromethyl)benzene

copper(I) cyanide

1-methoxy-3-nitro-5-trifluoromethyl-benzene

3,5-dinitrobenzotrifluoride

Downstream raw materials:

3-hydroxy-5-(trifluoromethyl)benzonitrile

(Z)-1-(3,3-difluoroazetidin-1-yl)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)prop-2-en-1-one

(Z)-azetidin-3-yl 3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate

(Z)-3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylic acid

Refernces

• 1、 -. "2,3-DIHYDROIMIDAZO[1,2-C] PYRIMIDIN-5(1H)-ONE COMPOUNDS USE AS LP-PLA2 INHIBITORS". Page/Page column 44. . Retrieved 2013/03/26.