16β-(1H-1,2,4-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17β-yl acetate

Base Information

Chemical Name:16β-(1H-1,2,4-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17β-yl acetate
CAS No.:1332954-08-1
Molecular Formula:C₃₁H₄₄N₄O₂
Molecular Weight:504.716
Hs Code.:

Synonyms:16β-(1H-1,2,4-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17β-yl acetate

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Chemical Property of 16β-(1H-1,2,4-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17β-yl acetate

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Technology Process of 16β-(1H-1,2,4-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17β-yl acetate

There total 5 articles about 16β-(1H-1,2,4-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17β-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1334215-51-8
16β-(1H-1,2,4-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17β-ol

: 108-24-7
acetic anhydride

: 1332954-08-1
16β-(1H-1,2,4-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17β-yl acetate

Guidance literature:: With dmap; In dichloromethane; at 40 ℃;
DOI:10.1016/j.ejmech.2011.05.030

Reference yield:

: 28507-02-0
16α-bromo-3β-hydroxy-5α-androstan-17-one

: 1332954-08-1
16β-(1H-1,2,4-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17β-yl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: Jones reagent / acetone / 0 °C

2: acetonitrile / 24 h / 80 °C

3: sodium cyanoborohydride; acetic acid / methanol / 24 h / 40 °C / pH Ca_. 6

4: sodium tetrahydroborate / methanol / 4 h / 0 °C

5: dmap / dichloromethane / 40 °C

With dmap; sodium tetrahydroborate; Jones reagent; sodium cyanoborohydride; acetic acid; In methanol; dichloromethane; acetone; acetonitrile;
DOI:10.1016/j.ejmech.2011.05.030

Reference yield:

: 1332954-26-3
16β-(1H-1,2,4-triazol-1-yl)-5α-androstan-3,17-dione

: 1332954-08-1
16β-(1H-1,2,4-triazol-1-yl)-3β-(N-benzylmethylamino)-5α-androstan-17β-yl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid / methanol / 24 h / 40 °C / pH Ca_. 6

2: sodium tetrahydroborate / methanol / 4 h / 0 °C

3: dmap / dichloromethane / 40 °C

With dmap; sodium tetrahydroborate; sodium cyanoborohydride; acetic acid; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.05.030