4-trifluoromethylphenylglyoxyl chloride

Base Information

Chemical Name:4-trifluoromethylphenylglyoxyl chloride
CAS No.:1314185-55-1
Molecular Formula:C₉H₄ClF₃O₂
Molecular Weight:236.578
Hs Code.:

Synonyms:4-trifluoromethylphenylglyoxyl chloride

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Chemical Property of 4-trifluoromethylphenylglyoxyl chloride

Chemical Property:

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Technology Process of 4-trifluoromethylphenylglyoxyl chloride

There total 4 articles about 4-trifluoromethylphenylglyoxyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 79478-02-7
4-(trifluoromethyl)phenylglyoxylic acid

: 1314185-55-1
4-trifluoromethylphenylglyoxyl chloride

Guidance literature:: With Dichloromethyl methyl ether; at 0 - 50 ℃; for 3.25h; Inert atmosphere;
DOI:10.1002/adsc.201100108

Reference yield:

: 73790-06-4
ethyl 2-oxo-2-(4-(trifluoromethyl)phenyl)acetate

: 1314185-55-1
4-trifluoromethylphenylglyoxyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / 2 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

With oxalyl dichloride; water; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane;
DOI:10.1021/ol403480v

Reference yield:

: 402-43-7
p-trifluoromethylphenyl bromide

: 1314185-55-1
4-trifluoromethylphenylglyoxyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / 1 h / 20 °C

1.2: 1 h / -78 - -10 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 6 h / Reflux

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

With oxalyl dichloride; water; magnesium; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201400147