Technology Process of 4-trifluoromethylphenylglyoxyl chloride
There total 4 articles about 4-trifluoromethylphenylglyoxyl chloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Dichloromethyl methyl ether;
at 0 - 50 ℃;
for 3.25h;
Inert atmosphere;
DOI:10.1002/adsc.201100108
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide; water / 2 h / 20 °C
2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere
With
oxalyl dichloride; water; N,N-dimethyl-formamide; sodium hydroxide;
In
dichloromethane;
DOI:10.1021/ol403480v
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: magnesium / tetrahydrofuran / 1 h / 20 °C
1.2: 1 h / -78 - -10 °C
2.1: sodium hydroxide; water / tetrahydrofuran / 6 h / Reflux
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C
With
oxalyl dichloride; water; magnesium; N,N-dimethyl-formamide; sodium hydroxide;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201400147
