N-(2-bromophenyl)-N-methyl-2-oxo-2-(4-(trifluoromethyl)phenyl)acetamide

Base Information

• Chemical Name: N-(2-bromophenyl)-N-methyl-2-oxo-2-(4-(trifluoromethyl)phenyl)acetamide
• CAS No.: 1206913-01-0
• Molecular Formula: C₁₆H₁₁BrF₃NO₂
• Molecular Weight: 386.168

Synonyms:N-(2-bromophenyl)-N-methyl-2-oxo-2-(4-(trifluoromethyl)phenyl)acetamide

Chemical Property of N-(2-bromophenyl)-N-methyl-2-oxo-2-(4-(trifluoromethyl)phenyl)acetamide

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Technology Process of N-(2-bromophenyl)-N-methyl-2-oxo-2-(4-(trifluoromethyl)phenyl)acetamide

There total 1 articles about N-(2-bromophenyl)-N-methyl-2-oxo-2-(4-(trifluoromethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-trifluoromethylphenylglyoxyl chloride (1314185-55-1) + 2-bromo-N-methylaniline (6832-87-7) → N-(2-bromophenyl)-N-methyl-2-oxo-2-(4-(trifluoromethyl)phenyl)acetamide (1206913-01-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/b917958e

Reference yield: 90.0%

N-(2-bromophenyl)-N-methyl-2-oxo-2-(4-(trifluoromethyl)phenyl)acetamide (1206913-01-0) → 3-hydroxy-1-methyl-3-(4-(trifluoromethyl)phenyl)indolin-2-one (1206913-11-2)

Guidance literature:

With bis(bipyridine)nickel(II) bromide; zinc; In tetrahydrofuran; acetonitrile; at 75 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.03.069

Reference yield: 82.0%

N-(2-bromophenyl)-N-methyl-2-oxo-2-(4-(trifluoromethyl)phenyl)acetamide (1206913-01-0) → N-(2-bromophenyl)-2-hydroxy-N-methyl-2-(4-(trifluoromethyl)phenyl)acetamide (1335113-52-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c1cc14209g

upstream raw materials:

4-trifluoromethylphenylglyoxyl chloride

2-bromo-N-methylaniline

Downstream raw materials:

3-hydroxy-1-methyl-3-(4-(trifluoromethyl)phenyl)indolin-2-one

N-(2-bromophenyl)-2-hydroxy-N-methyl-2-(4-(trifluoromethyl)phenyl)acetamide

4-methyl-2-(4-(trifluoromethyl)phenyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

2,4-dimethyl-2-(4-(trifluoromethyl)phenyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

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