2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carbonitrile

Base Information

Chemical Name:2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carbonitrile
CAS No.:1402652-36-1
Molecular Formula:C₂₀H₁₉N₃O₂
Molecular Weight:333.39
Hs Code.:

Synonyms:2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carbonitrile

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Chemical Property of 2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carbonitrile

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Technology Process of 2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carbonitrile

There total 8 articles about 2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1156-51-0,25722-66-1
2,2-bis(4-cyanatophenyl)propane

: 1402652-35-0
4-(3-(4-methoxyphenyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrol-2-yl)-3,5-dimethylisoxazole

: 1402652-36-1
2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carbonitrile

Guidance literature:: 2,2-bis(4-cyanatophenyl)propane; 4-(3-(4-methoxyphenyl)-1,4,5,6-tetrahydrocyclopenta[b]pyrrol-2-yl)-3,5-dimethylisoxazole; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;

With water; at 0 ℃;

Reference yield:

: 35166-20-2
1-(3,5-dimethyl-1,2-oxazol-4-yl)ethanone

: 1402652-36-1
2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper(ll) bromide / ethyl acetate / 3 h / 75 °C

2.1: N-ethylmorpholine; / toluene / 16 h / 110 °C / Sealed vial

2.2: 2 h / 20 °C

3.1: 1,1,1,3,3,3-hexamethyl-disilazane; acetic acid / methanol / 15 h / 130 °C / Inert atmosphere; Sealed vial

4.1: N-Bromosuccinimide / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.1: dmap; triethylamine / acetonitrile / 1.5 h / Inert atmosphere

6.1: potassium carbonate; sodium iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.5 h / 90 °C / Inert atmosphere

7.1: sodium methylate; methanol / tetrahydrofuran / 16 h / 45 °C / Inert atmosphere

8.1: sodium hydride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

8.2: 0 °C

With N-ethylmorpholine;; methanol; dmap; N-Bromosuccinimide; sodium methylate; sodium hydride; potassium carbonate; acetic acid; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; sodium iodide; copper(ll) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; toluene; acetonitrile;

Reference yield:

: 1402652-33-8
tert-butyl 3-bromo-2-(3,5-dimethylisoxazol-4-yl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carboxylate

: 1402652-36-1
2-(3,5-dimethylisoxazol-4-yl)-3-(4-methoxyphenyl)-5,6-dihydrocyclopenta[b]pyrrole-1(4H)-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; sodium iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.5 h / 90 °C / Inert atmosphere

2.1: sodium methylate; methanol / tetrahydrofuran / 16 h / 45 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3.2: 0 °C

With methanol; sodium methylate; sodium hydride; potassium carbonate; sodium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water;