trifluoromethanesulfonic acid 8-phenylsulfonyl-7-methyl-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl ester

Base Information

Chemical Name:trifluoromethanesulfonic acid 8-phenylsulfonyl-7-methyl-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl ester
CAS No.:253195-81-2
Molecular Formula:C₁₆H₁₄F₃NO₆S₂
Molecular Weight:437.417
Hs Code.:

Synonyms:trifluoromethanesulfonic acid 8-phenylsulfonyl-7-methyl-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trifluoromethanesulfonic acid 8-phenylsulfonyl-7-methyl-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl ester

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Technology Process of trifluoromethanesulfonic acid 8-phenylsulfonyl-7-methyl-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl ester

There total 5 articles about trifluoromethanesulfonic acid 8-phenylsulfonyl-7-methyl-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 185198-49-6
8-phenylsulfonyl-6-hydroxy-7-methyl-2,3-dihydroi-1H-ndolizin-5-one

: 253195-81-2
trifluoromethanesulfonic acid 8-phenylsulfonyl-7-methyl-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jo9911600

Reference yield: 86.0%

: phenylbis[(trifluoromethyl)sulfonyl]amine

: 185198-49-6
8-phenylsulfonyl-6-hydroxy-7-methyl-2,3-dihydroi-1H-ndolizin-5-one

: 253195-81-2
trifluoromethanesulfonic acid 8-phenylsulfonyl-7-methyl-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl ester

Guidance literature:: With triethylamine;
DOI:10.1021/jo961690l

Reference yield:

: 907969-47-5
1-(phenylsulfonylacetyl)pyrrolidin-2-one

: 253195-81-2
trifluoromethanesulfonic acid 8-phenylsulfonyl-7-methyl-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / Et₃N; p-acetamidophenylsulfonyl azide / acetonitrile / 0 - 20 °C

2: 51 percent / Rh(OAc)2 / benzene / 12 h / Heating

3: 86 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

With rhodium(II) acetate; 4-acetamidobenzenesulfonyl azide; triethylamine; In dichloromethane; acetonitrile; benzene; 1: Substitution / 2: Cycloaddition / 3: Substitution;
DOI:10.1021/jo9911600