2-nitro-N-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-benzenesulfonamide

Base Information

• Chemical Name: 2-nitro-N-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-benzenesulfonamide
• CAS No.: 292819-40-0
• Molecular Formula: C₁₇H₂₆N₂O₆S
• Molecular Weight: 386.469
• Mol file: 292819-40-0.mol

Synonyms:2-nitro-N-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-benzenesulfonamide

Chemical Property of 2-nitro-N-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-nitro-N-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-benzenesulfonamide

There total 1 articles about 2-nitro-N-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

3,4-dihydro-2H-pyran (110-87-2) + 6-amino-1-hexanol (4048-33-3) + 2-Nitrobenzenesulfonyl chloride (1694-92-4) → 2-nitro-N-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-benzenesulfonamide (292819-40-0)

Guidance literature:

6-amino-1-hexanol; 2-Nitrobenzenesulfonyl chloride; With sodium hydroxide; In water; ethyl acetate;

3,4-dihydro-2H-pyran; With toluene-4-sulfonic acid;

DOI:10.1016/S0040-4039(00)00711-5

Reference yield: 95.0%

2-nitro-N-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-benzenesulfonamide (292819-40-0) + 2-[4-(4-Benzyloxy-benzyloxycarbonyl)-benzyl]-2-((Z)-4-hydroxy-but-2-enyl)-malonic acid dimethyl ester → 2-[4-(4-Benzyloxy-benzyloxycarbonyl)-benzyl]-2-((Z)-4-{(2-nitro-benzenesulfonyl)-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-amino}-but-2-enyl)-malonic acid dimethyl ester

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1016/S0040-4039(00)00711-5

Reference yield:

2-nitro-N-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-benzenesulfonamide (292819-40-0) → (Z)-10-(2-Nitro-benzenesulfonyl)-2-oxo-3-oxa-10-aza-bicyclo[15.2.2]henicosa-1(20),12,17(21),18-tetraene-15,15-dicarboxylic acid dimethyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / DEAD; Ph₃P / tetrahydrofuran / 5 h / 20 °C

2: 90 percent / TFA; phosphate buffer / CH₂Cl₂; methanol / 19 h / 20 °C / pH 7

3: 28 percent / DEAD; Ph₃P / tetrahydrofuran / 4 h / 20 °C

With phosphate buffer; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; 1: Mitsunobu reaction / 2: Hydrolysis / 3: Cyclization;

DOI:10.1016/S0040-4039(00)00711-5

upstream raw materials:

3,4-dihydro-2H-pyran

6-amino-1-hexanol

2-Nitrobenzenesulfonyl chloride

Downstream raw materials:

2-(4-Carboxy-benzyl)-2-{(Z)-4-[(6-hydroxy-hexyl)-(2-nitro-benzenesulfonyl)-amino]-but-2-enyl}-malonic acid dimethyl ester