2-(2-benzyloxy-4-formyl-6-nitro-phenyl)-malonic acid dimethyl ester

Base Information

• Chemical Name: 2-(2-benzyloxy-4-formyl-6-nitro-phenyl)-malonic acid dimethyl ester
• CAS No.: 312731-71-8
• Molecular Formula: C₁₉H₁₇NO₈
• Molecular Weight: 387.346
• Mol file: 312731-71-8.mol

Synonyms:2-(2-benzyloxy-4-formyl-6-nitro-phenyl)-malonic acid dimethyl ester

Chemical Property of 2-(2-benzyloxy-4-formyl-6-nitro-phenyl)-malonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-benzyloxy-4-formyl-6-nitro-phenyl)-malonic acid dimethyl ester

There total 4 articles about 2-(2-benzyloxy-4-formyl-6-nitro-phenyl)-malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

dimethyl malonate sodium salt (18424-76-5) + trifluoro-methanesulfonic acid 2-benzyloxy-4-formyl-6-nitro-phenyl ester (312731-70-7) → 2-(2-benzyloxy-4-formyl-6-nitro-phenyl)-malonic acid dimethyl ester (312731-71-8)

Guidance literature:

In N,N-dimethyl-formamide; for 1h;

DOI:10.1021/ja0013879

Reference yield:

isonitrovanillin (6635-20-7) → 2-(2-benzyloxy-4-formyl-6-nitro-phenyl)-malonic acid dimethyl ester (312731-71-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / HBr; AcOH / H₂O / 8 h / Heating

2: 85 percent / NaH / dimethylformamide

3: 95 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

4: 80 percent / dimethylformamide / 1 h

With pyridine; hydrogen bromide; sodium hydride; acetic acid; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja0013879

Reference yield:

3,4-dihydroxy-5-nitrobenzaldehyde (116313-85-0) → 2-(2-benzyloxy-4-formyl-6-nitro-phenyl)-malonic acid dimethyl ester (312731-71-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / NaH / dimethylformamide

2: 95 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

3: 80 percent / dimethylformamide / 1 h

With pyridine; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja0013879

upstream raw materials:

dimethyl malonate sodium salt

trifluoro-methanesulfonic acid 2-benzyloxy-4-formyl-6-nitro-phenyl ester

isonitrovanillin

3,4-dihydroxy-5-nitrobenzaldehyde

Downstream raw materials:

2-(2-benzyloxy-4-hydroxymethyl-6-nitro-phenyl)-malonic acid dimethyl ester

2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-malonic acid dimethyl ester

allyl-{3-benzyloxy-5-benzyloxymethyl-2-[1-(4-methoxy-benzyloxymethyl)-2-triisopropylsilanyloxy-ethyl]-phenyl}-carbamic acid 2,2,2-trichloro-ethyl ester

allyl-{3-benzyloxy-5-benzyloxymethyl-2-[1-(4-methoxy-benzyloxymethyl)-2-triisopropylsilanyloxy-ethyl]-phenyl}-carbamic acid tert-butyl ester