Trifluoro-Methanesulfonicacid2-benzyloxy-4-forMyl-6-nitro-phenylester

Base Information

• Chemical Name: Trifluoro-Methanesulfonicacid2-benzyloxy-4-forMyl-6-nitro-phenylester
• CAS No.: 312731-70-7
• Molecular Formula: C15H10F3NO7S
• Molecular Weight: 405.308
• Mol file: 312731-70-7.mol

Synonyms:Trifluoro-methanesulfonic acid 2-benzyloxy-4-formyl-6-nitro-phenyl ester;

Chemical Property of Trifluoro-Methanesulfonicacid2-benzyloxy-4-forMyl-6-nitro-phenylester

Chemical Property:

• PSA: 123.87000
• LogP: 4.81870

Purity/Quality:

97% ^*data from raw suppliers

2-(Benzyloxy)-4-formyl-6-nitrophenyltrifluoromethanesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Trifluoro-Methanesulfonicacid2-benzyloxy-4-forMyl-6-nitro-phenylester

There total 3 articles about Trifluoro-Methanesulfonicacid2-benzyloxy-4-forMyl-6-nitro-phenylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trifluoromethylsulfonic anhydride (358-23-6) + 3-benzyloxy-4-hydroxy-5-nitro-benzaldehyde (312327-13-2) → trifluoro-methanesulfonic acid 2-benzyloxy-4-formyl-6-nitro-phenyl ester (312731-70-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ja0013879

Reference yield:

isonitrovanillin (6635-20-7) → trifluoro-methanesulfonic acid 2-benzyloxy-4-formyl-6-nitro-phenyl ester (312731-70-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / HBr; AcOH / H₂O / 8 h / Heating

2: 85 percent / NaH / dimethylformamide

3: 95 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; hydrogen bromide; sodium hydride; acetic acid; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ja0013879

Reference yield:

3,4-dihydroxy-5-nitrobenzaldehyde (116313-85-0) → trifluoro-methanesulfonic acid 2-benzyloxy-4-formyl-6-nitro-phenyl ester (312731-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NaH / dimethylformamide

2: 95 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja0013879

upstream raw materials:

trifluoromethylsulfonic anhydride

3-benzyloxy-4-hydroxy-5-nitro-benzaldehyde

isonitrovanillin

3,4-dihydroxy-5-nitrobenzaldehyde

Downstream raw materials:

2-(2-benzyloxy-4-formyl-6-nitro-phenyl)-malonic acid dimethyl ester

(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-acetoxy-2-(2-benzyloxy-4-hydroxymethyl-6-nitro-phenyl)-propyl ester

(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-3-acetoxy-2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-propyl ester

2-(2-benzyloxy-4-dimethoxymethyl-6-nitro-phenyl)-propane-1,3-diol