4-Benzyloxy-butyric acid (1S,2S)-2-{4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-1-methyl-butyl ester

Base Information

Chemical Name:4-Benzyloxy-butyric acid (1S,2S)-2-{4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-1-methyl-butyl ester
CAS No.:221615-79-8
Molecular Formula:C₄₈H₅₄F₂N₈O₆
Molecular Weight:877.004
Hs Code.:

4-Benzyloxy-butyric acid (1S,2S)-2-{4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-1-methyl-butyl ester

Synonyms:4-Benzyloxy-butyric acid (1S,2S)-2-{4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-1-methyl-butyl ester

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Chemical Property of 4-Benzyloxy-butyric acid (1S,2S)-2-{4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-1-methyl-butyl ester

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Technology Process of 4-Benzyloxy-butyric acid (1S,2S)-2-{4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-1-methyl-butyl ester

There total 3 articles about 4-Benzyloxy-butyric acid (1S,2S)-2-{4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-1-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 10385-30-5
4-(benzyloxy)butanoic acid

: 171228-49-2
posaconazote

: 221615-79-8
4-Benzyloxy-butyric acid (1S,2S)-2-{4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-1-methyl-butyl ester

Guidance literature:: With dmap; p-toluenesulfonyl chloride; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0040-4039(01)01485-X

Reference yield:

: 93903-27-6
benzyl 4-(benzyloxy)butanoate

: 221615-79-8
4-Benzyloxy-butyric acid (1S,2S)-2-{4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-1-methyl-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH; water / toluene / 24 h / Heating

2: 90 percent / TsCl; DMAP / tetrahydrofuran / 0 °C

With dmap; sodium hydroxide; water; p-toluenesulfonyl chloride; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4039(01)01485-X

Reference yield:

: 100-39-0
benzyl bromide

: 221615-79-8
4-Benzyloxy-butyric acid (1S,2S)-2-{4-[4-(4-{4-[(3R,5R)-5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylmethyl-tetrahydro-furan-3-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl}-1-methyl-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: KOH / toluene / 72 h / Heating

2: NaOH; water / toluene / 24 h / Heating

3: 90 percent / TsCl; DMAP / tetrahydrofuran / 0 °C

With dmap; potassium hydroxide; sodium hydroxide; water; p-toluenesulfonyl chloride; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4039(01)01485-X