ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

Base Information

Chemical Name:ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate
CAS No.:1332388-83-6
Molecular Formula:C₂₂H₁₆F₄N₄O₃S
Molecular Weight:492.454
Hs Code.:

Synonyms:ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

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Chemical Property of ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

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Technology Process of ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

There total 6 articles about ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73792-06-0
ethyl-4-amino-2-fluorobenzoate

: 1332388-83-6
ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 80 °C

2.1: N,N-dimethyl acetamide / 70 °C

2.2: 2 h / Reflux

In N,N-dimethyl acetamide; acetic acid;

Reference yield:

: 573762-62-6
5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile

: 463-71-8
thiophosgene

: 1332392-08-1
ethyl 4-((1-cyanocyclobutyl)amino)-2-fluorobenzoate

: 1332388-83-6
ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

Guidance literature:: 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile; thiophosgene; ethyl 4-((1-cyanocyclobutyl)amino)-2-fluorobenzoate; In N,N-dimethyl acetamide; at 70 ℃;

With hydrogenchloride; water; In methanol; N,N-dimethyl acetamide; for 2h; Reflux;

Reference yield:

: 887707-23-5
2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine

: 1332388-83-6
ethyl 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluorobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / N,N-dimethyl-formamide / 4 h / 110 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 2 h / Reflux; Inert atmosphere

3.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 170 °C / Reflux; Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

5.1: N,N-dimethyl acetamide / 70 °C

5.2: 2 h / Reflux

With trifluoroacetic acid; sodium t-butanolate; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;